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中国应用生理学杂志 ›› 2015, Vol. 31 ›› Issue (4): 332-336.doi: 10.12047/j.cjap.0114.2015.009

• 研究论文 • 上一篇    下一篇

正常人左心室功能指标的参考值及其预计公式的初步研究报告*

卢志南1, 孙兴国1,△, Songshou Mao2, Matthew J. Budoff2, William W. Stringer2, 葛万刚1, 李浩1, 黄洁1, 刘方1, 胡盛寿1   

  1. 1.中国医学科学院 北京协和医学院 国家心血管病中心阜外医院 心血管疾病国家重点实验室,心血管疾病国家临床医学研究中心, 北京 100037;
    2.美国加州大学洛杉矶分校Harbor-UCLA 医学中心,洛杉矶生物医学研究院,圣约翰心血管研究中心,美国 加州90502
  • 收稿日期:2015-01-13 修回日期:2015-06-05 发布日期:2021-11-12
  • 通讯作者: Tel: 010-88398300, E-mail: xgsun@labiomed.org
  • 基金资助:
    *国家自然科学基金医学科学部面上项目(81470204); 国家高新技术研究发展计划(863计划)课题(2012AA021009); 中国医学科学院国家心血管病中心科研开发启动基金(2012-YJR02)

Normal reference values and predict equations of heart function

LU Zhi-nan1, SUN Xing-guo, MAO Song-shou2, BUDOFF MJ2, STRINGER WW2, GE Wan-gang1, LI Hao1, HUANG Jie1, LIU Fang1, Hu Sheng-shou1   

  1. 1. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Research Center of Clinic Medicine for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China;
    2. Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, University of California at Los Angeles, St. John's Cardiovascular Research Center, California 90502,USA
  • Received:2015-01-13 Revised:2015-06-05 Published:2021-11-12

摘要: 目的: 当前评估左心室容量和功能仍常用正常值范围,个体化分析也仅使用体表面积进行校正。尚缺少个体化因素相关的大样本参考值和预计公式。方法: 本研究纳入美国加州洛杉矶县南湾地区1200名健康志愿者,其中男807女393,年龄20岁-94岁,心脏CT造影(CTA),经过高精度三维成像技术处理,计算左心室容积在收缩和舒张过程中的连续动态变化,测定左心室(LV)容量和功能指标:舒张末期容积(EDV)、收缩末期容积(ESV)、每搏输出量(SV)、射血分数(EF)和心输出量(CO)。将以上指标与一般特征指标进行多因素相关分析,以探索正常人预计值计算公式。结果: 男性除LVEF小于女性外(P<0.001),其余各指标均大于女性(P<0.001)。多元线性回归分析提示, 性别、年龄、身高和体质量均为EDV、ESV、SV的独立影响因子(P<0.001); 而CO仅受年龄、性别、体质量显著影响(P<0.001),但与身高无关(P>0.05)。CO的预测公式CO (L·min-1)= 6.963+0.446(Male) -0.037×年龄(yr)+0.013×体质量(kg)。结论: 性别、年龄、身高、体质量均影响左心室容量和功能,建立预测值计算公式,对心血管疾病的无创评估和个体化精准医疗具有重要参考价值。

关键词: 多层螺旋CT, 心脏CT造影, 三维立体成像技术, 心脏功能, 心输出量, 每博心输出量, 左心室容量, 左室射血分数, 参考值, 预计值公式

Abstract: Objective: For heart functional parameters, we commonly used normal range. The reference values and predict formulas of heart functional parameters and their relationships with individual characteristics are still lack. Methods: Left ventricular (LV) volumes (end-diastolic volume and end-systolic volume), stroke volume(SV), ejection fraction(EF) and cardiac output (CO) were measured by cardiac CT angiography (CAT) in 1 200 healthy Caucasian volunteers, men 807 and women 393, and age 20~90yr. The results are analyzed by high-accuracy three-dimensional imaging technology, and then measured the dynamic changes of the volumes of each atriam and ventricule during their contractions and relaxations. The gender, age, height and weight were analyzed by multiple linear regression to predict LV functional parameters. Results: Except the LVEF was lower in man than in women (P<0.001), all other LV functional parameters of EDV, ESV, SV, FE and CO were higher in man (P<0.001). Multiple linear regression indicated that age, gender, height and weight are all independent factors of EDV, ESV and SV (P<0.001). CO could be significantly predicted by age, gender and weight (P<0.001), but not height (P>0.05). The predict equation for CO (L·min-1)= 6.963+0.446(Male)-0.037×age (yr) +0.013×weight (kg). Conclusion: Age, gender, height and weight are predictors of heart functions. The reference values and predict equations are important for noninvasive and accurate evaluation of cardiovascular disease and individualized treatment.

Key words: multi-slices computed tomography, cardiac computed tomography angiography, three dimensional graphology, cardiac function, cardiac output, stroke volume, left ventricular volume, left ventricular ejection fraction, reference value, predict equation

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