12周太极拳运动对中老年轻度高血压患者微血管反应性的影响及机制*

doi:10.12047/j.cjap.6164.2021.080

中国应用生理学杂志 ›› 2021, Vol. 37 ›› Issue (6): 683-687.doi: 10.12047/j.cjap.6164.2021.080

12周太极拳运动对中老年轻度高血压患者微血管反应性的影响及机制^*

胡庆华^1,2, 乾佑玲³, 刘晓丽^1,2△, 朱欢^1,2, 肖杰文^1,2

1.湖北民族大学体育学院, 恩施 445000;
2.恩施州太极拳爱好者协会, 恩施 445000;
3.武汉理工大学体育部, 武汉 430070

收稿日期:2020-09-22 修回日期:2021-01-22 出版日期:2021-11-28 发布日期:2021-11-25
通讯作者: ^△Tel: 13997774639; E-mail: yixuelau@163.com
基金资助:
^*湖北省教育厅省级教研项目(2018383);2020年湖北省教育厅人文社科重大项目(202D068)

Effects of 12-week Tai Chi exercise on the microvascular reactivity of the middle-aged and elderly patients with mild hypertension and its mechanism

HU Qing-hua^1,2, QIAN You-ling³, LIU Xiao-li^1,2△, ZHU Huan^1,2, XIAO Jie-wen^1,2

1. Institution of Sports of Hubei Nationalities College, EnShi 445000;
2. Enshi State Taijiquan Amateur Association, EnShi 445000;
3. Sports Department of Wuhan University of Technology, Wuhan 430070, China

Received:2020-09-22 Revised:2021-01-22 Online:2021-11-28 Published:2021-11-25

摘要/Abstract

摘要： 目的:研究12周太极拳运动对中老年轻度高血压患者微血管反应性的影响,并探讨微血管反应性变化的机制。方法:将30名轻度高血压患者分为运动组(53.8±6.3岁)和对照组(52.6±7.5岁),两组人数及性别比例相同。运动组进行12周的太极拳运动,对照组保持原先的生活方式且不做其它规律性的体育运动。两组受试者分别于运动干预前、第6周和第12周结束后进行微血管反应性、血压及血清一氧化氮含量、一氧化氮合酶活性测试。结果:试验前,两组受试者各指标的基础值均无显著差异(P＞0.05)。运动组,第6周微血管反应性、收缩压、舒张压、一氧化氮含量、一氧化氮合酶活性较基础值无显著变化(P＞0.05),第12周微血管反应性、一氧化氮含量和钙依赖型一氧化氮合酶活性较基础值及对照组显著升高(P＜0.05),收缩压和舒张压较基础值和对照组显著下降(P＜0.05)。对照组,第6周、第12周各指标较基础值均无显著变化(P＞0.05)。结论:12周太极拳运动能提高中老年轻度高血压患者微血管反应性、降低血压,并能提高患者一氧化氮含量、钙依赖型一氧化氮合酶活性,内源性一氧化氮生成增加是太极拳运动提高高血压患者微血管反应性的生物学机制之一。

关键词: 太极拳, 轻度高血压, 中老年, 微血管反应性, 一氧化氮, 一氧化氮合酶

Abstract: Objective: To study the effects of 12-week Taijiquan exercise on the microvascular reactivity of middle-aged and elderly patients with mild hypertension and to explore the mechanisms of microvascular reactivity. Methods: Thirty patients with mild hypertension were divided into exercise group (53.8±6.3 years old) and control group (52.6±7.5 years old). The number and gender ratio of the two groups were the same. The exercise group performed Tai Chi exercise for 12 weeks, and the control group maintained the original lifestyle and did not do other regular sports. The two groups of subjects were tested for microvascular reactivity, blood pressure, serum nitric oxide content, and nitric oxide synthase activity before exercise intervention, 6th week and 12th week, respectively. Results: There was no significant difference in the basic values of each index between the two groups of subjects before the test (P＞ 0.05). In the 6th week, the microvascular reactivity (blood flow increase rate), systolic blood pressure, diastolic blood pressure, nitric oxide content, nitric oxide synthase activity of the exercise group did not significantly change from the basic value (P＞0.05). At the 12th week, the microvascular reactivity, nitric oxide content, c nitric oxide synthase activity were significantly higher than those of the base values and the control group (P＜0.05), but the systolic blood pressure and diastolic blood pressure were significantly lower than those of the base values and control group (P＜0.05). In the control group, there were no significant changes in the 6th and 12th week values of each index from the basic value (P＞0.05). Conclusion: Twelve weeks of Taijiquan exercise can improve the microvascular reactivity of middle-aged hypertensive patients, reduce blood pressure, and increase the nitric oxide content and c nitric oxide synthase of patients. The increase of endogenous nitric oxide production is one of the biological mechanisms of Tai Chi exercise to improve the microvascular responsiveness of hypertension patients.

Key words: Tai Chi, mild hypertension, middle-aged and elderly, microvascular reactivity, nitric oxide, nitric oxide synthase

中图分类号:

G804.5

胡庆华, 乾佑玲, 刘晓丽, 朱欢, 肖杰文. 12周太极拳运动对中老年轻度高血压患者微血管反应性的影响及机制^*[J]. 中国应用生理学杂志, 2021, 37(6): 683-687.

HU Qing-hua, QIAN You-ling, LIU Xiao-li, ZHU Huan, XIAO Jie-wen. Effects of 12-week Tai Chi exercise on the microvascular reactivity of the middle-aged and elderly patients with mild hypertension and its mechanism[J]. CJAP, 2021, 37(6): 683-687.

参考文献

[1] 李金根, 马立永, 张立晶. 高血压诊治热点研究进展[J]. 医学综述, 2020, 26 (23): 4666-4671.
[2] Tang DH, Bai S, Li XL, et al. Improvement of microvascular endothelial dysfunction induced by exercise and diet is associated with microRNA-126 in obese adolescents[J]. Micro Res, 2019, 123(5): 86-91.
[3] PadroT, Manfrini O, Bugiardini R et al. ESC working group on coronary pathophysiology and microcirculation position paper on 'coronary microvascular dysfunctionin cardiovascular disease'[J]. Cardiovasc Res, 2020, 116(2): 1-15.
[4] 王雪强. 运动干预改善高血压的效果可能不亚于药物[J]. 上海体育学院学报, 2020, 44(4): 49.
[5] Holloway TM, Bloemberg D, da Silva ML, et al. High-intensity interval and endurance training are associated with divergent skeletal muscle adaptations in a rodent model of hypertension.[J]. Am J Physiol Regul Integr Comp PhysioAm, 2015, 308: R927-34.
[6] 吴聪, 吴迎, 马珮冬, 等. 有氧运动对自发性高血压大鼠骨骼肌毛细血管稀疏的影响[J]. 中国动脉硬化杂志, 2018, 26(7): 691-697.
[7] 朱欢, 高炳宏. 有氧运动对人体微血管反应性的作用及机制研究进展[J]. 生命科学, 2020, 32(8): 855-863.
[8] 金成吉, 张自云, 解超. 太极拳对中老年原发性高血压患者血压水平影响的Meta分析[J]. 现代预防医学, 2018, 45(18): 3446-3451.
[9] 朱欢, 高炳宏. 微血管反应性在耐力性运动员训练中的应用[J]. 中国运动医学杂志, 2019, 38(10): 907-914.
[10] Minson C T. Thermal provocation to evaluate microvascular reactivity in human skin [J]. J Appl Physiol, 2010, 109(4): 1239-1246.
[11] Moraes RD,Van Bavel D, Gomes MDB, et al. Effects of non-supervised low intensity aerobic excise training on the microvascular endothelial function of patients with type 1 diabetes: a non-pharmacological interventional study[J]. BMC Cardi Dis, 2016, 16 (1): 1-9.
[12] 韩冬柏, 刘晓宇, 李娜, 等. 微循环障碍与高血压关系的研究进展[J]. 实用心脑肺血管病杂志, 2020, 28(5): 112-115.
[13] 张昊楠, 高炳宏, 朱欢. 男子赛艇运动员赛前6周训练微循环血流储备能力与相关生化指标的关系[J]. 中国应用生理学杂志, 2017, 33(2): 112-116.
[14] 朱欢, 高炳宏, 梁世雷, 等. 我国赛艇运动员肱二头肌微循环血流储备能力的研究[J]. 中国应用生理学杂志, 2015, 31(1): 61-65.
[15] 朱欢, 胡庆华, 彭爱萍, 等. 长期太极拳运动对中老年人膝关节皮肤微血管反应性、经皮氧分压的影响[J]. 中国应用生理学杂志, 2020, 36(04): 321-323.
[16] 刘晓丽, 刘超能, 王人卫, 等. 心肺功能在健康风险预测中的应用[J]. 中国运动医学杂志, 2018, 37(2): 158-165.
[17] Conti FF, Brito Jde O, Bernardes N, et al. Positive effect of combined exercise training in a model of metabolic syndrome and menopause: autonomic,inflammatory andoxidative stress evaluations[J]. Am J Physiol Regul Integr Comp Physiol, 2015, 309(12): R1532-R1539.
[18] Mikus CR, Rector RS, Arce-Esquivel AA. Daily physical activity enhance reactivity to insulin in skeletal muscle arterioles of hyperphagic otsuka long-evans tokushima fatty rats[J]. J Appl Physiol, 2010, 109(4): 1203-1210.
[19] 任可欣, 陶袁. 不同强度健步走锻炼对中老年人血清一氧化氮含量的影响[J]. 大连民族大学学报, 2016, 18(6): 600-602.
[20] 王艳霞, 刘海斌, 刘波, 等. 运动对动脉内皮功能的调控及血流剪切力的介导作用[J]. 北京生物医学工程, 2017, 36(6): 639-647.

12周太极拳运动对中老年轻度高血压患者微血管反应性的影响及机制^*

Effects of 12-week Tai Chi exercise on the microvascular reactivity of the middle-aged and elderly patients with mild hypertension and its mechanism

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	王永胜, 皇甫尚峰, 王楠, 宋清华. 广场舞和健步走对中老年女性身心健康的影响[J]. 中国应用生理学杂志, 2021, 37(3): 297-299.
[2]	朱梅菊, 毛泽华, 郭红英, 朱洪竹, 丁孝民. 石菖蒲及α-细辛醚对疲劳运动大鼠学习记忆的影响及其机制^*[J]. 中国应用生理学杂志, 2020, 36(4): 306-311.
[3]	朱欢, 胡庆华, 彭爱萍, 万利. 长期太极拳运动对中老年人膝关节皮肤微血管反应性、经皮氧分压的影响^*[J]. 中国应用生理学杂志, 2020, 36(4): 321-323.
[4]	刘朝猛, 吴懿姿, 周丽云. 广西边疆农村地区老人跌倒发生率、风险评估及太极拳结合肌力、平衡训练防跌倒效果^*[J]. 中国应用生理学杂志, 2020, 36(2): 180-183.
[5]	于富洋, 杨胜昌, 郭亚净, 赵亚硕, 刘思文, 吉恩生. 消痰化瘀利窍方对慢性间歇性低氧大鼠肠系膜动脉损伤的改善作用^*[J]. 中国应用生理学杂志, 2019, 35(3): 204-208.
[6]	孙焱, 曾青芝, 赵丹, 李鑫. 广场舞锻炼对中老年女性身心健康的影响[J]. 中国应用生理学杂志, 2018, 34(3): 246-248.
[7]	范斌. 不同步数的健步走对男性中老年人健身的效果[J]. 中国应用生理学杂志, 2018, 34(2): 126-129.
[8]	刘善云, 张翔, 孙江波, 李倩男, 刘悦, 连志强, 张德荣. 10周核心力量练习对男性中老年人平衡能力的影响[J]. 中国应用生理学杂志, 2017, 33(4): 365-368.
[9]	杨锐, 贾强, 马善峰, 刘小粉, 高琴, 王蕾. 硫化氢对1型糖尿病大鼠膈肌NO含量和iNOS活性的影响[J]. 中国应用生理学杂志, 2017, 33(3): 248-251.
[10]	王志旺, 王永辉, 任远, 王瑞琼, 蔺兴遥, 段海婧. 丁苯酞对豚鼠平喘作用的初步药效学观察[J]. 中国应用生理学杂志, 2017, 33(2): 136-139.
[11]	曹峰. 长期有氧运动对中老年人甲襞微循环的影响[J]. 中国应用生理学杂志, 2017, 33(2): 178-180.
[12]	栗亮, 高原. 大鼠正中视前核注射血管紧张素Ⅱ(ANGⅡ)对某些肾脏功能指标的影响[J]. 中国应用生理学杂志, 2017, 33(1): 37-39.
[13]	丁露, 郑青青, 李洋, 陈宣颖, 陈然, 王雪瑞, 龚永生, 范小芳. 儿茶酚抑素在大鼠肾性高血压中的作用及可能机制[J]. 中国应用生理学杂志, 2016, 32(3): 214-218.
[14]	柳磊, 时飒, 李鸿珠, 李弘, 徐长庆. 激活多巴胺I类受体对氧化性低密度脂蛋白诱导的人单核细胞THP-1分泌NO/NOS的影响[J]. 中国应用生理学杂志, 2016, 32(3): 274-277.
[15]	陈丽娜, 周刚, 吴乐, 侯少华. NADPH氧化酶抑制剂apocynin对力竭运动大鼠运动性蛋白尿的影响[J]. 中国应用生理学杂志, 2016, 32(2): 116-120.