首页  期刊介绍 征稿简则 编委会 期刊征订 广告服务 留言板 联系我们 English

中国应用生理学杂志 ›› 2016, Vol. 32 ›› Issue (3): 245-249.doi: 10.13459/j.cnki.cjap.2016.03.015

• 研究论文 • 上一篇    下一篇

筋骨草提取物抗运动疲劳的作用

文婷1,2, 皮建辉1,3, 谭娟1,3, 胡朝暾1,3, 向德标1,3   

  1. 1. 怀化学院生命科学系, 湖南 怀化 418008;
    2. 贵州师范大学生命科学学院, 贵阳 550001;
    3. 怀化学院民族药用植物资源研究与利用湖南省重点实验室, 怀化 418008
  • 收稿日期:2015-03-25 修回日期:2015-10-15 出版日期:2016-05-28 发布日期:2018-06-12
  • 通讯作者: 皮建辉,Tel:13574578248;E-mail:pijh817@126.com E-mail:pijh817@126.com
  • 基金资助:
    “民族药用植物资源研究与利用”湖南省重点实验室委托研究项目(YYZW201404);湖南省重点学科建设项目(湘教发[2011]42号)

Effects of the extracts from Ajuga decumbens on anti-fatigue in mice

WEN Ting1,2, PI Jian-hui1,3, TAN Juan1,3, HU Zhao-tun1,3, XIANG De-biao1,3   

  1. 1. Department of Life Science, Huaihua University, Huaihua 418008;
    2. College of Life Science, Guizhou Namoral University, Guiyang 550001;
    3. Laboratory of Hunan Province for Study and Utilization of Ethnic Medicinal Plant Resources, Huaihua University, Huaihua 418008, China
  • Received:2015-03-25 Revised:2015-10-15 Online:2016-05-28 Published:2018-06-12
  • Supported by:
    “民族药用植物资源研究与利用”湖南省重点实验室委托研究项目(YYZW201404);湖南省重点学科建设项目(湘教发[2011]42号)

摘要: 目的:探讨筋骨草的抗运动性疲劳作用。方法:将120只雄性昆明种小鼠随机平均分成安静组、运动组、阳性对照组和筋骨草低、中、高剂量组(n=10)。其中低、中、高剂量组小鼠分别按100 mg/kg、200 mg/kg、400 mg/kg体重连续灌胃筋骨草提取物30 d,阳性对照组小鼠按200 mg/kg体重灌胃西洋参胶囊颗粒,安静组和运动组小鼠以等体积生理盐水灌胃。动物试验结束后,分析各组小鼠运动力竭时间、血清生理生化指标(包括血乳酸、血尿素氮、血糖、总胆固醇、甘油三酯含量)、肝糖原与肌糖原含量,以及股四头肌、肝脏和心脏组织的抗氧化指标(包括谷胱甘肽过氧化物酶、超氧化物歧化酶、过氧化氢酶和丙二醛)。结果:中、高剂量组小鼠的运动力竭时间、红细胞数量、血红蛋白含量、血糖浓度、肝糖原与肌糖原含量,以及器官组织中谷胱甘肽过氧化物酶、超氧化物歧化酶和过氧化氢酶活力均明显高于运动对照组,而血清乳酸含量、血清尿素氮、血清甘油三酯与总胆固醇含量,以及器官组织中丙二醛含量明显低于运动对照组,中剂量的筋骨草提取物的作用效果优于同剂量的西洋参胶囊颗粒。结论:筋骨草通过提高机体的抗氧化功能而达到抗运动性疲劳作用。

关键词: 筋骨草, 抗疲劳, 抗氧化, 小鼠

Abstract: Objective:To investigate the effects of extracts from Ajuga decumbens on anti-fatigue in mice. Methods:One hundred and twenty female Kunming (KM) mice were randomly divided into quiet control group, sport control group, positive control group and 3 experimental groups which were the low, medium and high dose group given the extracts from Ajuga decumbens. The low, medium and high dose group were given the extracts with 100 mg/kg, 200 mg/kg, 400 mg/kg by body weight of mice for 30 d, respectively, but the positive control group was given American ginseng granules, while the quiet control group and the sport control groups were treated with saline. After this, the exhausting time, the physio-biochemical indexes (including lactic acid, blood urea nitrogen, blood sugar, total cholesterol and triglyceride) in serum, the contents of muscle and liver glycogen, and the antioxidative indexes (including glutathione peroxidase, superoxide dismutase, catalase and malondialdehyde) of organs in mice were investigated. Results:The exhausting time, the number of red blood cell, the contents of hemoglobin and blood sugar, the contents of muscle and liver glycogen, and the activities of glutathione peroxidase, superoxide dismutase and catalase in organs of mice in the medium dose group and the high dose group were significantly more than those of the sport control group, but the contents of blood lactic acid, blood urea nitrogen and that of triglyceride and total cholesterol in serum, and the content of malondialdehyde in organs of mice in the medium dose group and the high dose group were significantly lower than those of the sport control group. And the effect of medium dose extracts from Ajuga decumbens on anti-fatigue was better than that of American ginseng granules. Conclusion:The extracts from Ajuga decumbens has significant anti-fatigue effect in mice.

Key words: Ajuga decumbens Thunb(Traditional Chinese Medicine), anti-fatigue effect, anti-oxidant, rat

版权所有 © 2015 《中国应用生理学杂志》编辑部
京ICP备16058274号-1
地址:天津市和平区大理道1号,邮编:300050  电话:022-84655184  E-mail:tjzgyish@163.com
本系统由北京玛格泰克科技发展有限公司设计开发 技术支持:support@magtech.com.cn