优秀长跑运动员NADPH氧化酶p22phox亚基基因多态性分子标记的探讨*

doi:10.12047/j.cjap.5850.2019.110

中国应用生理学杂志 ›› 2019, Vol. 35 ›› Issue (6): 506-509.doi: 10.12047/j.cjap.5850.2019.110

优秀长跑运动员NADPH氧化酶p22phox亚基基因多态性分子标记的探讨^*

周文婷^1,2△, 胡扬

1. 遵义师范学院体育学院, 贵州遵义 563006;
2. 哈尔滨体育学院学术理论研究部, 黑龙江哈尔滨 150001;
3. 北京体育大学科学研究中心, 北京 100084

收稿日期:2019-03-26 出版日期:2019-11-28 发布日期:2020-04-02
通讯作者: 国家自然科学基金(31071032);2018年度黑龙江省省属高等学校基本科研业务费科研项目(2018KYYWF-FC07);2018年黑龙江省教育厅“冰雪运动学”特色学科专项重点项目(BXZD001)

Feasibility study of using SNPs in the NADPH oxidase p22phox gene as molecular marker for talent selection of long distance runner

ZHOU Wen-ting, HU Yang

Received:2019-03-26 Online:2019-11-28 Published:2020-04-02

摘要/Abstract

摘要： 目的:解析NADPH 氧化酶p22^phox(NADPH Oxidase p22phox, CYBA)基因的C242T、A930G和A675T多态位点,探讨用于我国北方汉族优秀长跑运动员分子选材标记的可行性。方法:选取优秀长跑运动员123人作为运动员组,127名中国北方汉族普通大学生为对照组,采用基质辅助激光解吸附电离飞行时间质谱检测技术,对CYBA基因的C242T、A930G和A675T位点进行解析并分析比较。结果:与对照组相比,运动员组A930G和A675T位点的基因型和等位基因频率均无显著性差异(P＞0.05),而C242T位点的TC基因型在5 km/10 km运动员组的分布频率存在显著性差异(P＜0.05)。结论:C242T位点的TC基因型可作为5 km/10 km优秀运动员选材的分子标记。

关键词: NADPH 氧化酶p22phox基因, 基因多态性, 长跑运动员, 遗传标记

Key words: CYBA, polymorphisms, long-distance runner, genetic mark

中图分类号:

G408.7

周文婷, 胡扬. 优秀长跑运动员NADPH氧化酶p22phox亚基基因多态性分子标记的探讨^*[J]. 中国应用生理学杂志, 2019, 35(6): 506-509.

ZHOU Wen-ting, HU Yang. Feasibility study of using SNPs in the NADPH oxidase p22phox gene as molecular marker for talent selection of long distance runner[J]. CJAP, 2019, 35(6): 506-509.

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优秀长跑运动员NADPH氧化酶p22phox亚基基因多态性分子标记的探讨^*

Feasibility study of using SNPs in the NADPH oxidase p22phox gene as molecular marker for talent selection of long distance runner

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