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中国应用生理学杂志 ›› 2015, Vol. 31 ›› Issue (4): 326-329.doi: 10.12047/j.cjap.0112.2015.007

• 研究论文 • 上一篇    下一篇

建立正常人肺血管容量的无创精确测量方法的初步报告*

孙兴国1,2, Songshou Mao2, Matthew J. Budoff2, William W. Stringer2, 程显声1   

  1. 1.中国医学科学院 北京协和医学院 国家心血管病中心阜外医院 心血管疾病国家重点实验室, 国家心血管疾病临床医学研究中心, 北京 100037;
    2.美国加州大学洛杉矶分校Harbor-UCLA医学中心,洛杉矶生物医学研究院,圣约翰心血管研究中心,美国 加州90502
  • 收稿日期:2015-06-05 修回日期:2015-07-05 发布日期:2021-11-12
  • 通讯作者: Tel: 010-88398300, E-mail: xgsun@labiomed.org
  • 基金资助:
    *国家自然科学基金医学科学部面上项目(81470204); 国家高新技术研究发展计划(863计划)课题(2012AA021009); 中国医学科学院国家心血管病中心科研开发启动基金(2012-YJR02)

Preliminary reports of noninvasive accurate method to measure pulmonary vascular capacity in normal volunteers

SUN Xing-guo1,2, MAO Song-shou2, BUDOFF MJ2, STRINGER WW2, CHENG Xian-sheng1   

  1. 1. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Research Center of Clinic Medicine for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China;
    2. Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, University of California at Los Angeles, St. John's Cardiovascular Research Center, California 90502, USA
  • Received:2015-06-05 Revised:2015-07-05 Published:2021-11-12

摘要: 目的: 由于传统呼吸调控环路忽略了对血液循环的决定性作用,肺(静脉)血管容量相关研究甚少,亟需建立肺血管容量测量方法。方法: 选择正常志愿者完成CT全肺扫描,图像数据经过计算机软件分析处理,从肺尖到肺底以40~50层进行肺野手工切划,相邻层间由计算机自动模拟连接,在去除干扰后进行全肺血管(≥0.6 mm)高精度三维立体成像技术处理,进而计算全肺和肺血管容积。结果: 12例正常志愿者从肺尖到肺底CT扫描图片层数为530±98(431~841)张。全肺和肺血管的总容积是3705±857(2398~5383)ml ,肺血管血液总的容积是125±32(94~201)ml。按肺静脉系统血管容量约为全肺血管血液容量一半计算,应该是63±16(47~100)ml。结论: 肺CT扫描数据分析三维立体成像建立肺血管容量无创测量方法精确可行。

关键词: 肺脏CT扫描, 肺血管总容量, 肺血管树, 肺静脉血管容量

Abstract: Objective: Because the traditional loop of breathing control and regulation effect on blood circulation, there was rare study of pulmonary vein capacity.We need a noninvasive and accurate pulmonary vascular capacity measurement and analysis method. Methods: Twelve normal volunteers were performed a total lung CT scan, image data analysis processing by computer software, the whole lungs from the apex to the base of lung with 40~50 layers by hand-cut, the connection between adjacent layers automatically by a computer simulation, the full pulmonary vascular (≥0.6 mm) were treated by high-accuracy three-dimensional imaging technology after removing the interference, and then calculate the whole lung and pulmonary vascular. Results: The whole lung of the 12 normal volunteers from the apex to the base of lung CT scan image layers was 530±98(range, 431~841). The total capacity of lung and pulmonary vascular blood was 3705±857(range, 2398~5383)ml, and the total volume of the pulmonary vascular blood was 125±32(range, 94~201)ml. The pulmonary vein vascular blood volume was 63±16(range, 47~100)ml. Conclusion: The method of measuring the three-dimensional imaging of pulmonary vascular capacity by analyzing lung CT scan data is available and accurate.

Key words: lung CT scan, total capacity of the pulmonary vascular, pulmonary vascular tree, pulmonary vein blood volume

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