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CJAP ›› 2021, Vol. 37 ›› Issue (2): 169-176.doi: 10.12047/j.cjap.0076.2021.121

• ORIGINAL ARTICLES • Previous Articles     Next Articles

Relationship of characteristic duration and magnitude of the oscillatory breathing related with exercise functional capacity in patients with chronic heart failure

LYU Jing1,2,3, LI Zhen-ci1,2,3, SUN Xing-guo1,3, William Stringer3   

  1. 1. National Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, State Key Laboratory of Cardiovascular Diseases, National Center for Cardiovascular Diseases Clinical Medical Research, Peking Union Medical College, Beijing 100037, China;
    2. Guangzhou First People's Hospital, Guangzhou 510180, China;
    3. Harbor-UCLA Medical Center, Los Angel, California, USA
  • Received:2020-08-12 Revised:2021-03-20 Online:2021-03-28 Published:2021-10-20

Abstract: Objective: To find out the relationship between the duration and amplitude of oscillatory breathing (OB) and their exercise capacity in patients with chronic heart failure (CHF) we did this study. Methods: Two hundred and thirty-seven CHF patients performed a maximum incremental upright cycle ergometry cardiopulmonary exercise testing (CPET). Respiratory gas exchange was measured on a breath-by-breath basis throughout the test. OB was defined as 3 or more continuous cycle fluctuations of ventilation during CPET, and the amplitude of VE oscillations exceed 25% of concurrent mean value. The CHF patients with OB (OB+) were divided into 3 sub-groups according to their Peak VO2. Group1 (mild OB+) Peak VO2 of ≥16 ml/min/kg, group 2 (moderate OB+) Peak VO2 is between 12~16 ml/min/kg, group 3 (severe OB+) Peak VO2 ≤ 12 ml/(min·kg). Results: There were 78(32.6%) patients detected as OB+ in 237 CHF patients. Among OB+ patients, OB duration in s related negatively to Peak VO2 in mL/min/kg (r=-0.82), Peak VO2 in %pred (r=-0.65), VO2 at AT (r=-0.78), and related positively to VE/VCO2 at AT (r=0.61). Conclusion: OB duration is related negatively to exercise capacity of CHF patients.

Key words: chronic heart failure, cardiopulmonary exercise testing, oscillatory breathing, duration of oscillatory breathing, gas exchange

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