Preliminary study of clinical significance of decreased DLCO in patients with left ventricular heart failure

doi:10.12047/j.cjap.0120.2015.015

Abstract

Abstract: Objective: This study aimed to investigate the feature of D_LCO (Diffusion Lung Capacity for Carbon Monoxide) in CHF (left ventricular heart failure) patients, underlying pathophysiological mechanism and clinical significance. Methods: We retrospectively studied the D_LCO, pulmonary ventilation function, cardiopulmonary exercise testing and related clinical information in severer HF patients. Results: Peak VO₂ severely decreased to 34±7 percentage of predicted(%pred) and anaerobic threshold to 48±11%pred in all patients. D_LCO moderately decreased to 63±12%pred and there were 25 patients lower than 80%pred. FVC, FEV₁ , FEV₁/FVC and TLC were 75±14%pred, 71±17%pred , 97±11%pred, and 79±13%pred, which indicated borderline or mild restrictive ventilatory dysfunction. The decrease of D_LCO was more severe than those of TLC, FEV1 and FVC. Conclusion: For patients with severe CHF, cardiopulmonary exercise function is extremely limited, D_LCO generally moderately declines and ventilation function is merely mildly limited. D_LCO is the parameter for cardiopulmonary coupling, reflecting limitation of the cardiovascular dysfunction while without ventilatory limit.

Key words: chronic heart failure, diffusion lung capacity for carbon monoxide, pulmonary function test, cardiopulmonary exercise testing, integrated holistic physiology, integrated holistic medicine, new theory

CLC Number:

R541.6+1

TAN Xiao-yue, SUN Xing-guo, HU Sheng-shou, ZHANG Jian, HUANG Jie, CHEN Zhi-gao, MA Li. Preliminary study of clinical significance of decreased D_LCO in patients with left ventricular heart failure[J]. CJAP, 2015, 31(4): 357-360.

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Preliminary study of clinical significance of decreased D_LCO in patients with left ventricular heart failure

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