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CJAP ›› 2017, Vol. 33 ›› Issue (2): 117-120.doi: 10.12047/j.cjap.5416.2017.030

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Effects of dietary corn peptide and exercise on hepatic ATGL and TNF-α in obese rats

SUN Peng, TIAN Xiang-yang, SHI Reng-fei   

  1. Shanghai University of Sports, College of Life Science, Shanghai 200438, China
  • Received:2016-01-15 Revised:2016-11-02 Online:2017-03-28 Published:2018-06-20
  • Supported by:

Abstract: Objective: To determine whether dietary corn peptides supplementation with or without exercise on body composition and fac-tors related to hepatic lipid metabolism in obese rats induced by a high fat diet. Methods: Male SD rats were fed a high-fat diet (40% calorie as fat) for 8 weeks as a dietary induced obesity model (DIO, n=32). They were then randomly divided into four groups, control, corn pip-tide(CP) group, exercise group and CP + exercise group (n=8). Supplement (CP:200 g/kg) and exercise(tread mill Ex was performed 15 m/min for 60 min/d, 5 days a week) protocol for 4 weeks. Body weight and dietary levels of rats were monitored during the experimental peri-od. At the end of the 4th weeks, rats of all groups were sacrificed. Perirenal fat and liver were harvested, and hepatic adipose triglyceride li-pase(ATGL) and TNF-α were analyzed via Western blot. Results: After 4 weeks, compared with DIO control group, body weight and perire-nal fat mass index in CP + exercise group were significantly decreased (P < 0.05). Hepatic ATGL was significantly higher in corn peptides supplementation, especially in combination with exercise (P < 0.05). At the same time, the values of TNF-α expression were decreased signif-icantly in exercise groups compared with DIO group (P < 0.05). Conclusion: Corn peptides combined with aerobic exercise has a weight re-duction by lowering adipose tissue in experimental animals, it may be related to the expression of ATGL and TNF-α in the liver, and promote lipid metabolism.

Key words: obesity, corn peptide, aerobic exercise, ATGL

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