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CJAP ›› 2017, Vol. 33 ›› Issue (2): 136-139.doi: 10.12047/j.cjap.5463.2017.035

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Preliminary pharmacodynamics study on antiasthmatic action of butylphthalide in guinea pig

WANG Zhi-wang1,2, WANG Yong-hui3, REN Yuan1,2, WANG Rui-qiong1, LIN Xing-yao1, DUAN Hai-jing1   

  1. 1. Gansu University of Traditional Chinese Medicine, Lanzhou 730000;
    2. Key Laboratory of Pharmacology and Toxicology for Traditional Chinese Medicine of Gansu Province, Lanzhou 730000;
    3. Shanxi College of Traditional Chinese Medicine, Taiyuan 030024, China
  • Received:2016-06-13 Revised:2016-11-27 Online:2017-03-28 Published:2018-06-20
  • Supported by:
    国家自然科学基金项目(81460668);甘肃省自然科学基金项目(1310RJZA086,1606RJZA011);甘肃省中药药理与毒理学重点实验室开放基金项目(ZDSYS-KJ-2015-002,ZDSYS-KJ-2016-004)

Abstract: Objective: To study the anti-asthmatic effects of butylphthalide in guinea pig. Methods: This research included isolated tra-cheal smooth muscle and in vivo animal experiments. Antispasmodic effects of butylphthalide at the concentrations of 1, 10, 100 mg/L were observed through spasmodical tracheal smooth muscle of guinea pig induced by acetylcholine or histamine (n=10). After screened, the guinea pigs were divided into control group, model group, dexamethasone(DXM) group, high and low dose butylphthalide groups. The effects of butylphthalide on nitric oxide (NO), endothelin-1 (ET-1) and asthmatic behaviors were observed on the asthmatic guinea pigs that were stimu-lated six times by the excitation fluid (1% ACh:0.05% Hist=1:1). Results: Butylphthalide at the concentrations of 1、10、100 mg/L had an-ti-spasmodic effects on spasmodical tracheal smooth muscle of guinea pig (15.08 ±7.68、42.41 ±13.54、77.56 ±24.82 to acetylcholine, 19.40 ±7.60、56.84 ±11.72、76.35 ±19.40 to histamine), which showed a certain dose-effect relationship. Butylphthalide could prolong asth-matic incubation period (53.3 ±13.2、33.1 ±13.0), improve asthmatic behaviors, reduce NO in serum (78.71 ±19.40、84.75 ±20.97) and ET-1 in bronchoalveolar lavage fluid (24.30 ±5.80、28.50 ±6.31) (P < 0.05, 0.01). Conclusion: Butylphthalide has some effects of anti-asthma and one of the mechanisms is to relieve abnormal increase of NO and ET-1.

Key words: butylphthalide (BPL), antiasthma, guinea pig, nitric oxide (NO), endothelin-1(ET-1)

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