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CJAP ›› 2018, Vol. 34 ›› Issue (1): 74-77.doi: 10.12047/j.cjap.5534.2018.019

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Changes of some biochemical markers and cardiac function in New Zealand rabbits with chronic heart failure

ZHOU Ben-mei, GUO Xing-ming, ZHENG Yi-neng, LI Hong-quan   

  1. College of Bioengineering, Chongqing University, Chongqing Engineering Research Center for Medical Electronic Technology, Chongqing 400044, China
  • Received:2016-12-08 Revised:2016-12-25 Online:2018-01-28 Published:2018-06-19
  • Supported by:
    国家自然科学基金资助项目(31570003)

Abstract: Objective: This article investigated the changes of some biochemical markers and cardiac function in chronic heart failure (CHF), and provided the basis for the diagnosis of CHF.Methods: New Zealand rabbit CHF model was established using adriamycin (ADR). Twenty New Zealand rabbits were randomly divided into model group (n=15) and control group (n=5), injected with ADR and saline solution via the ear vein respectively, 2 times a week, lasting for 8 weeks. After that, myocardial enzymes, carotid artery pressure, echocardiogram (ECG) and phonocardiogram (PCG) of all New Zealand rabbits were detected and recorded.Results: Compared with control group, all parameters of the model group were changed significantly (P<0.05).Conclusion: CHF leads to myocardial damage in New Zealand rabbits, decreased systolic and diastolic function, cardiac reserve index can be used to assess cardiac function.

Key words: chronic heart failure, New Zealand rabbits, cardiac function, cardiac reserve index

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