Effects of aerobic exercise plus diet control on serum levels of total IGF-1 and IGF-1 binding protein-3 in female obese youths and adolescents

doi:10.12047/j.cjap.5571.2018.020

Abstract

Abstract: Objective: To investigate the effects of 4-week moderate aerobic exercise plus diet control on serum levels of total insulin-like growth factor 1(IGF-1) and IGF-1 binding protein-3 (IGFBP-3) as well as IGF-1 activity (reflected by molar ratio of IGF-1/IGFBP-3) in female obese adolescents and youths, and their possible role on fat loss, and improvement of glucose and lipid metabolism.Methods: Nine female obese youths (age:18~19 y) and 30 female obese adolescents (age:14~16 y) were recruited and undertook 4-week aerobic exercise such as swimming and jogging (6 days/week, twice a day, 2 h/time with 5 min rest per 30 min exercise) with gradual increase of intensity from low (heart rate immediately post-exercise of 1st week:100~120 beats/min) to moderate (heart rate immediately post-exercise of 2^nd-4^th weeks:120~140 beats/min) level, combined with a diet intervention (total daily energy intake of 1 400 or 1 600 kcal according to basal metabolism rate) in Shanghai Dianfeng weight loss enclosed camp. Nine normal weight young women and 9 female children matched at age and nationality were recruited as the normal control. Before and after the experimental period, anthropometric index (body weight, body mass index(BMI) and waist circumference), glucose and lipid metabolism parameters including fasting blood glucose (FBG), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride (TG); total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL), and serum levels of total IGF-1 and IGFBP-3 were measured, and IGF-1 activity was calculated in the obese and normal control female adolescents.Results: ①Compared with normal control, the serum levels of total IGF-1 and IGFBP-3 were decreased in the female obese youths and adolescents, and IGF-1 activity was reduced only in the obese female adolescents. ②The serum level of IGFBP-3 was down-regulated and IGF-1 activity was up-regulated while no change of serum total IGF-1 was induced by 4-week moderate aerobic exercise plus diet control, accompanied with significant decreases of body weight, BMI and waist circumference as well as improvement of glucose and lipid metabolism in the female obese youths and adolescents. Except for a positive association between the increased IGF-1 activity and the decreased waist circumference was found in the female obese youths by Pearson's correlation analysis, there was no relation of the decreased IGFBP-3, the increased IGF-1 activity with the improvements of anthropometric index and glucose and lipid metabolism in female obese youths and adolescents.Conclusion: The serum level of IGFBP-3 was down-regulated and the IGF-1 activity was up-regulated by 4-week moderate aerobic exercise plus diet control in female obese youths and adolescents. The increase of IGF-1 activity might be associated with the exercise-plus-diet-induced decrease of waist circumstance in female obese youths.

Key words: IGF-1, IGFBP-3, obesity, aerobic exercise plus diet

YANG Hong-fang, LIN Xiao-jing, WANG Xiao-hui. Effects of aerobic exercise plus diet control on serum levels of total IGF-1 and IGF-1 binding protein-3 in female obese youths and adolescents[J]. CJAP, 2018, 34(1): 78-82.

References

[1] 周慧敏, 向政. 6周有氧运动结合饮食控制对肥胖青少年身体形态及血液指标的影响[J]. 中国应用生理学杂志, 2017, 33(2):166-168.
[2] Keating SE, Hackett DA, Parker HM, et al. Effect of aerobic exercise training dose on liver fat and visceral adiposity[J]. J Hepatol, 2015, 63(1):174-182.
[3] Puche JE, Castilla-Cortazar I. Human conditions of insulin-like growth factor-I (IGF-I) deficiency[J]. J Transl Med, 2012, 10:224.
[4] Ranke MB. Insulin-like growth factor binding-protein-3(IGFBP-3)[J]. Best Pract Res Clin Endocrinol Metab, 2015, 29(5):701-711.
[5] Mohamad MI, Khater MS. Evaluation of insulin like growth factor-1(IGF-1) level and its impact on muscle and bone mineral density in frail elderly male. Arch Gerontol Geriatr, 2015, 60(1):124-127.
[6] You L, Liu C, Tang H, et al. Advances in targeting insulin-like growth factor signaling pathway in cancer treatment[J]. Curr Pharm Des, 2014, 20(17):2899-2911.
[7] Friedrich N, Thuesen B, Jorgensen T, et al. The Association Between IGF-I and Insulin Resistance A general population study in Danish adults[J]. Diabetes Care, 2012, 35(4):768-773.
[8] Aguirre GA, De Ita JR, De La Garza RG, et al. Insulin-like growth factor-1 deficiency and metabolic syndrome[J]. J Transl Med, 2016, 14:3.
[9] Berryman DE, Glad CA, List EO, et al. The GH/IGF-1 axis in obesity:pathophysiology and therapeutic considerations[J]. Nat Rev Endocrinol, 2013, 9(6):346-356.
[10] Liang S, Hu Y, Liu C, et al. Low insulin-like growth factor 1 is associated with low high-density lipoprotein cholesterol and metabolic syndrome in Chinese nondiabetic obese children and adolescents:a cross-sectional study[J]. Lipids Health Dis, 2016, 15:112.
[11] Miyake H, Kanazawa I, Sugimoto T. Decreased serum insulin-like growth factor-I level is associated with the increased mortality in type 2 diabetes mellitus[J]. Endocr J, 2016, 63(9):811-818.
[12] Lam CS, Chen MH, Lacey SM, et al. Circulating insulin-like growth factor-1 and its binding protein-3:metabolic and genetic correlates in the community. Arterioscler Thromb Vasc Biol, 2010, 30(7):1479-1484.
[13] Alberti C, Chevenne D, Mercat I, et al. Serum concentrations of insulin-like growth factor (IGF)-1 and IGF binding protein-3(IGFBP-3), IGF-1/IGFBP-3 ratio, and markers of bone turnover:reference values for French children and adolescents and z-score comparability with other references[J]. Clin Chem, 2011, 57(10):1424-1435.
[14] Wang Q, Yin J, Xu L, et al. Prevalence of metabolic syndrome in a cohort of Chinese schoolchildren:comparison of two definitions and assessment of adipokines as components by factor analysis[J]. BMC Public Health, 2013, 13:249.
[15] 邵威, 费加明. 不同运动方式对肥胖青少年减肥效果的比较[J]. 中国应用生理学杂志, 2017, 33(3):211-213.
[16] 沈友青, 徐祥峰, 代会莹. 大强度间歇运动与低强度持续运动对高脂喂养大鼠体成分、血脂、血糖及QUICKI指数的影响[J]. 卫生研究, 2016, 45(2):282-287.
[17] Majorczyk M, Smolag D. Effect of physical activity on IGF-1 and IGFBP levels in the context of civilization diseases prevention[J]. Rocz Panstw Zakl Hig, 2016, 67(2):105-111.
[18] Ben Ounis O, Elloumi M, Zouhal H, et al. Effect of individualized exercise training combined with diet restriction on inflammatory markers and IGF-1/IGFBP-3 in obese children[J]. Ann Nutr Metab, 2010, 56(4):260-266.
[19] Mason C, Xiao L, Duggan C, et al. Effects of dietary weight loss and exercise on insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in postmenopausal women:a randomized controlled trial[J]. Cancer Epidemiol Biomarkers Prev, 2013, 22(8):1457-1463.
[20] Romualdo MC, Nobrega FJ, Escrivao MA. Insulin resistance in obese children and adolescents[J]. J Pediatr (Rio J), 2014, 90(6):600-607.