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CJAP ›› 2019, Vol. 35 ›› Issue (4): 355-358.doi: 10.12047/j.cjap.5786.2019.075

• ORIGINAL ARTICLES • Previous Articles     Next Articles

Effects of puerarin on rats with type 2 diabetes mellitus

YANG Fei1, DONG Xin-xin2, GUO Yun1△   

  1. 1. Department of Endocrinology, Characteristic Medical Center of the Chinese People’s Armed Police Force, Tianjin 300162;
    2. Department of Surgical Oncology, Characteristic Medical Center of the Chinese People’s Armed Police Force, Tianjin 300162, China
  • Received:2018-11-20 Online:2019-07-28 Published:2019-11-06

Abstract: Objective: To investigate the therapeutic effects of puerarin on rats with type 2 diabetes mellitus (T2DM). Methods: T2DM models were established by high fat and high glucose feeding combined with a one-time intraperitoneal injection of streptozotocin (STZ, 60 mg/kg). Then the rats were randomly divided into normal group, model group, metformin group (MET, 40 mg/kg), puerarin low-dose group, medium-dose group and high-dose group (40, 80, 160 mg/kg), n=10. After the model was successfully established, rats were treated with corresponding drug intervention by intragastrical administration for 4 weeks. The body weight and fasting blood glucose (FBG) were measured per week, and blood samples were collected 24 h after the last administration, and serum levels of blood glucose, serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholestrol (HDL-C), serum enzyme activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), serum creatinine (SCr), and blood uric acid (UA) were measured. Results: As compared with normal group, the body weight was decreased after 4 weeks-intervention in the model group, and the levels of FBG, TC, TG, LDL-C, ALT, AST, BUN, SCr and UA were all increased,while HDL-C level was decreased (P<0.05). As compared with model group,the body weight was increased after 4 weeks-intervention in metformin group and puerarin groups, and the levels of FBG, TC, TG, LDL-C, ALT, AST, BUN, SCr and UA were decreased (P<0.01); meanwhile, HDL-C level was increased significantly (P<0.05). Conclusion: Puerarin can reduce the weight loss of T2DM rats, decrease the blood lipid and blood glucose levels of T2DM rats, which can be used to control T2DM.

Key words: puerarin, type 2 diabetes mellitus, blood glucose, blood lipid, rat

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