Dihydromyricetin ameliorates chronic social defeat stress induced cognitive and affective disorder in mice

doi:10.12047/j.cjap.5852.2019.108

Abstract

Abstract: Objective: To investigated the effects of dihydromyricetin on cognitive and affective disorders induced by chronic social defeat stress and its possible mechanism in mice. Methods: C57BL/6J mice were randomly divided into control group (Control), chronic social defeat stress group (CSDS) and chronic social defeat stress + DHM group (CSDS+DHM) (14 mice in each group). The mice received chronic social defeat stress and were injected with DHM or vehicle intraperitoneally. A part of mice were subjected to (10 mice of each group) novel object recognition test (NOR), Y maze test, open field test (OFT), social interaction test (SIT), forced swimming test (FST) and tail suspension test (TST). The other mice (4 mice of each group) were decapitated and the expression levels of SIRT1 in hippocampus were detected by Western blot. Results: Compared with the control group, the learning and memory of the CSDS group were reduced significantly, the anxiety level was increased significantly, the immobility time in TST and FST was increased significantly, and the SIRT1 protein level in hippocampus was reduced significantly (P＜ 0.05 or P＜ 0.01); Compared with the CSDS group, the learning and memory of the CSDS + DHM group were improved significantly, the anxiety level of the mice was reduced significantly, and the immobility time in TST and FST was reduced significantly. The protein level of SIRT1 in hippocampus was increased significantly (P＜ 0.05 or P＜ 0.01). Conclusion: DHM ameliorates the cognitive impairment, anxiety like behavior and depression like behavior of mice induced by CSDS and up-regulates the expression of SIRT1 protein.

Key words: dihydromyricetin, chronic social defeat stress, cognitive dysfunction, depression, anxiety, SIRT1

CLC Number:

WANG Le, LI Bi-rong, XIAO Zhi-yong, ZHAO Jin-long, YU Xu-dong. Dihydromyricetin ameliorates chronic social defeat stress induced cognitive and affective disorder in mice[J]. CJAP, 2019, 35(6): 496-500.

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