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CJAP ›› 2020, Vol. 36 ›› Issue (2): 97-100.doi: 10.12047/j.cjap.5871.2020.022

• ORIGINAL ARTICLES •     Next Articles

Effects of Radix Angelicae Sinensis on airway mucus hypersecretion and the TNF-α/NF-κB signaling pathway in Yin-deficiency asthmatic mice

YAO Nan1, WEI Ling-xia1, WANG Zhi-wang1,2△, DING Mao-peng1, FU Xiao-yan1, PANG Ya-rong1, CHENG Xiao-li1, LIN Xing-yao1,2, SHAO Jing1△   

  1. 1. Gansu College of Traditional Chinese Medicine, Lanzhou 730000;
    2. Key Laboratory of Pharmacology and Toxicology for Traditional Chinese Medicine of Gansu Province, Lanzhou 730000, China
  • Online:2020-03-28 Published:2020-07-31

Abstract: Objective: To investigate the therapeutic effects of Radix Angelicae Sinensis (RADA) on airway mucus hypersecretion and the tumor necrosis factor-α/ nuclear factor- κB (TNF-α/NF-κB) signaling pathway in Yin-deficiency asthma mice. Methods: KM mice were randomly divided into control group, model group, ambroxol group and RADA low, medium and high dose (2, 4 and 8 g/kg) group(n=12). Ovalbumin and the thyroid gland were used to replicate the model of Yin-deficiency asthma. Asthma symptoms in mice , immune globulin E (IgE) , TNF-α , and the expressions of Mucin 5ac (Muc5ac) and NF- κB in lung tissue were observed under the intervention of RADA. Results: RADA at the doses of 2,4 and 8 g/kg could alleviate the asthma symptoms of Yin-deficiency asthma mice significantly, reduce the levels of IgE in serum and TNF-α in bronchoalveolar lavage fluid (BALF), and inhibite the overexpressions of Muc5ac and NF- κB in lung tissue. Conclusion: RADA has significant anti-asthmatic effect. One of its mechanisms is to inhibit TNF-α/NF- κB signaling pathway and to alleviate airway mucus hypersecretion.

Key words: Radix Angelicae Sinensis (RADA), Yin-deficiency asthma, mouse, mucus hypersecretion, Alpha-tumor necrosis factor (TNF-α), NF-κB

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