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CJAP ›› 2020, Vol. 36 ›› Issue (2): 161-164.doi: 10.12047/j.cjap.5909.2020.036

• ORIGINAL ARTICLES • Previous Articles     Next Articles

Effects of swimming training on blood pressure and prethrombotic state molecules in hypertensive rats

DOU Li   

  1. Department of Physical Education, Nanjing Forestry University, Nanjing 210037, China
  • Online:2020-03-28 Published:2020-07-31

Abstract: Objective: To observe the effects of 10-week swimming training on blood pressure and prethrombotic state in spontaneously hypertensive rats (SHR). Methods: Eighteen 10-week-old male SHR were randomly divided into control group (8 rats) and training group (10 rats). The SHR training group underwent weightless swimming training for 10 weeks, five times a week, 60 minutes a time, and blood pressure was measured every two weeks. The platelet aggregation rate, von willebrand factor(vWF), tissue plasminogen activator(t-PA), plasminogen activator inhibitor –1(PAI-1) in plasma were measured after 10 weeks of training. Results: Compared with the control group, blood pressure in SHR training group was decreased significantly(P<0. 05) after 4-week of swimming training, and blood pressure, platelet aggregation rate, plasma vWF level, PAI-1 activity were decreased significantly(P<0. 01), while plasma t-PA activity was increased significantly (P<0. 01) after 10-week of swimming training. Conclusion: Suitable swimming training will effectively reduce the blood pressure of SHR and has a significant effect if persisting in training for 4 weeks, and it also can improve pre-thrombotic state, prevent hypertensive thrombotic complications significantly in SHR.

Key words: spontaneous hypertension, swimming training, prethrombotic state molecules, blood pressure, spontaneously hypertensive rats (SHR)

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