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CJAP ›› 2020, Vol. 36 ›› Issue (4): 301-305.doi: 10.12047/j.cjap.5932.2020.065

• ORIGINAL ARTICLES • Previous Articles     Next Articles

Effects of aerobic exercise combined with Lycium ruthenicum on some indicators of myocardial lipid metabolism in rats with high-fat diet

CUI Xiao-mei1, CAO Jian-min2, ZHANG Jing3,4, ZHOU Hai-tao3,4△, NIU Yan-long5, HU Ge6, GUO Xian2, LI Zhao-yan3   

  1. 1. Lanzhou University of Technology, Lanzhou 730050;
    2. Beijing Sport University, Beijing 100084;
    3. Biochemical Engineering College of Beijing Union University, Beijing 100023;
    4. Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191;
    5. Gannan Medical University, Ganzhou 341000;
    6. Changzhi Medical College, Changzhi 046000, China
  • Received:2019-09-02 Revised:2020-05-13 Published:2020-11-09

Abstract: Objective: To study the effects of aerobic exercise combined with Lycium ruthenicumon on some indicators of myocardial lipid metabolism in rats with high-fat diet. Methods: Fifty-five male Wistar rats were subjected to adaptive feeding for 4 days and weight-free swimming training for 3 days, 20 min/d. After eliminating 5 rats that were not suitable for swimming training, the others were randomly divided into 5 groups according to their weight: regular diet + quiet control group (RDC), high fat diet + quiet control group (HDC), high-fat diet + Lycium ruthenicum quiet control group (HDLC), high fat diet + aerobic exercise group (HDM), high fat diet + Lycium ruthenicum + aerobic exercise group (HDLM), 10 in each group. Group HDM and HDLM did 60 min/d swimming training for 6 weeks with no-bearing. Group C were fed regular diet; The other groups were fed with high-fat diet; Group HDLC and HDLM were intragastrically treated with Lycium ruthenicum at the dose of 4.48 g/(kg·d), and the volume was 5 mL/kg, and the other groups were given equivalent distilled water. The Lee's index, serum and myocardial biochemical indexes were measured after 6 weeks. Results: Compared with group RDC, Lee's index, serum free fatty acids (FFA), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), myocardial FFA and intercellular adhesion molecule-1 (ICAM-1) increased significantly (P<0.01), serum level of high-density lipoprotein cholesterol (HDL-C) decreased significantly (P<0.01) in group HDC. Compared with group HDC, Lee's index, serum FFA, IL-6, TNF-α, TC, TG, LDL-C, myocardial FFA and ICAM-1 decreased significantly (P<0.05 or P<0.01), serum HDL-C levels increased significantly (P<0.05 or P<0.01) in group HDLC, HDM and HDLM. Compared with group HDLC and HDM, Lee's index, serum FFA, IL-6, TNF-α, TC, TG, LDL-C, myocardial FFA and ICAM-1 decreased significantly (P<0.05), serum HDL-C level increased significantly (P<0.05) in group HDLM. Conclusion: Aerobic exercise and/or Lycium ruthenicum can improve lipid metabolism in rats with high-fat diet, reduce lipotoxicity caused by obesity. Combined intervention is more effective.

Key words: aerobic exercise, lycium ruthenicum, high-fat diet, rat, myocardium, lipid metabolism

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