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CJAP ›› 2020, Vol. 36 ›› Issue (5): 499-502.doi: 10.12047/j.cjap.6005.2020.106

• ORIGINAL ARTICLES • Previous Articles     Next Articles

Preventive and therapeutic effects of Qiwei Yugan Granule on hepatic fibrosis in rats

CHENG Xiao-li1, ZHAO Yu-zhu1, WANG Zhi-wang1△, DING Mao-peng1, WEI Ling-xia1, PAN Hong2△   

  1. 1.Gansu University of Chinese Medicine, Lanzhou 730000;
    2.Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China
  • Received:2020-01-16 Revised:2020-07-08 Published:2021-02-25

Abstract: Objective: To investigate the preventive and therapeutic effects of Qiwei Yugan Granule (QYG) on hepatic fibrosis in rats based on MMP-13/TIMP-1 imbalance. Methods: The rats were randomly divided into control group, model group, colchicine group (1.0×10-4 g/kg) and QYG treated groups (3.7, 7.4, 14.8 g/kg) (n=8). The rat model of hepatic fibrosis was established by injected with carbon tetrachloride subcutaneously for 4 weeks and treated with ethanol by gavage for 6 weeks. The effects of QYG on liver function, histopathology of liver, related indexes of serum liver fibrosis, and MMP-13, TIMP-1 in hepatic tissue were observed. Results: QYG at the doses of 14.8、7.4、3.7 g/kg could significantly decrease the serum levels of ALT, AST, HA, PCⅢ and C-Ⅳ, relieve the pathological changes of hepatic fibrosis, increase the activity of MMP-13, decrease the activity of TIMP-1 and alleviate the imbalance of MMP-13/TIMP-1. Among them, QYG had a certain trend of dose-effect relationship with TIMP-1 and MMP-13/TIMP-1 (P<0.05, 0.01). Conclusion: QYG has the effect of preventing and treating liver fibrosis and one of mechanisms is to promote MMP-13/TIMP-1 to restore balance.

Key words: Qiwei Yugan Granule (QYG), hepatic fibrosis, rat, therapeutic effect, matrix metalloproteinase - 13 (MMP-13) /tissue inhibitor of metalloproteinase - 1 (TIMP-1)

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