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CJAP ›› 2021, Vol. 37 ›› Issue (5): 486-489.doi: 10.12047/j.cjap.6086.2021.059

• ORIGINAL ARTICLES • Previous Articles     Next Articles

Effect of nuclear radiation on rat model of decompression sickness induced by large depth rapid floating escape

XU Ji, FANG Yi-qun, BAO Xiao-chen, YUAN Heng-rong, WANG Nan, WANG Fang-fang   

  1. Department of Diving and Hyperbaric Medicine, Naval Characteristic Medical Center, Naval Medical University, Shanghai 200433, China
  • Received:2020-05-09 Revised:2021-02-01 Online:2021-09-28 Published:2021-11-24

Abstract: Objective: To investigate the effects of different doses of nuclei exposure at different time on morbidity, mortality, and damage indicators in a rat model of decompression sickness caused by rapid flotation escape at a large depth. Methods: Eighty male SD rats were randomly divided into blank control group, escape control group and six intervention groups (escape at 4 hours after 4 Gy radiation, escape at 4 hours after 6 Gy radiation, escape at 4 hours after 12 Gy radiation, escape at 8 hours after 4 Gy radiation, escape at 8 hours after 6 Gy radiation, escape at 8 hours after 12 Gy radiation). Rats in intervention groups were exposed to different doses of γ-ray (4,6,12 Gy, respectively), and then were carried out a large depth and rapid buoyancy escape experiment (maximum pressure depth of 150 m). The changes of lung W/D, spleen index and plasma IL-1β levels were analyzed. Results: Compared with the blank control group, decompression sickness incidence and mortality of rats in escape groups after nuclear exposure were increased significantly. In 4 Gy and 6 Gy irradiation groups, higher morbidity and mortality were observed in rats which escaped at 4 h post nuclear exposure when compared with rats in 8 h groups. Consistent with the changes in morbidity and mortality, the wet / dry ratio of lung tissue, the pathological damage of lung tissue, and the decrease of spleen index showed the same trends: the changes were obvious at 4 h after lower doses nuclear radiation (4 Gy and 6 Gy), not at 8 h. However, these indicators all changed markedly at 4 and 8 h after higher doses nuclear radiation (12 Gy). Plasma IL-1β levels were significantly increased in each post-radiation exposure group when compared with the blank control group and the exposed control group. Conclusion: Nuclear radiation-induced lung injury, the damaged immune function and elevated plasma inflammatory factor concentrations increase the risk of decompression sickness after rapid ascent.

Key words: nuclear radiation, rapid floating escape, decompression sickness, lung injury, inflammatory factors, rats

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