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CJAP ›› 2021, Vol. 37 ›› Issue (3): 240-246.doi: 10.12047/j.cjap.6105.2021.028

• ORIGINAL ARTICLES • Previous Articles     Next Articles

Effects of B-GOS on cognitive behavior and depression of transgenic mice with Alzheimer's disease

YANG Dan1, QIAO Jing1, WANG Jia-xin2, WEI Wu-yang3, ZHAO Zi-xin2, CAI Hong-yan1△   

  1. 1. Department of Microbiology and Immunology, Shanxi Medical University,
    2. Department of Anesthesiology, Shanxi Medical University,
    3. Department of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China
  • Online:2021-05-28 Published:2021-08-09

Abstract: Objective: To investigate the effects of novel BimunoGalactooligosaccharides (B-GOS) on cognitive behavior and depression of APP/PS1/tau Alzheimer's disease transgenic mice. Methods: Five-month-old male APP/PS1/tau AD transgenic mice and C57BL/6J control mice were divide into C57+Vehicle group, C57+B-GOS group, APP/PS1/tau+Vehicle group and APP/PS1/tau+B-GOS group, with 10 mice in each group. After continuous administration of B-GOS for 5 months, the cognitive behavior and depressive mood changes of mice in each group were detected by open field experiment, new object recognition experiment, Y maze experiment, Morris water maze experiment, tail suspension test, forced swimming test and conditioned fear experiment, respectively. Results: ①Open field experiment: the percentage of activity time in the central area of open field in APP/PS1/tau+Vehicle group mice was significantly lower than that in C57+Vehicle group mice (P<0.01), and was remarkably increased after B-GOS intervention (P<0.05). ② New object recognition experiment: the new object recognition index (NOI) of APP/PS1/tau+Vehicle group mice was significantly lower than that of C57+Vehicle group mice (P<0.01), and was observably increased after B-GOS intervention (P<0.05). ③ Y maze experiment: the spontaneous alternation correct rate of APP/PS1/tau+Vehicle group mice was notably lower than that in C57+Vehicle group (P<0.01), and was distinctly increased after B-GOS intervention (P<0.01). ④ Classical water maze experiment: the escape latency of APP/PS1/tau+Vehicle group mice on the 4th and 5th days was significantly longer than that of C57+Vehicle group mice (P<0.01), which was markedly shortened after B-GOS intervention (P<0.05). During the space exploration phase, the percentage of swimming time in the target quadrant and the times of crossing the platform in APP/PS1/tau+Vehicle group mice were significantly lower than those in C57+Vehicle group mice (P<0.01), which were notably increased after B-GOS intervention (P<0.01). ⑤ Tail suspension test and forced swimming test: the percentage of immobility time in APP/PS1/tau+Vehicle group mice was dramatically higher than that in C57+Vehicle group mice (P<0.01), and was obviously reduced after B-GOS intervention (P< 0.01). ⑥ Conditioned fear experiment: before conditioned stimulus (CS), the freezing ratio of mice in each group had no statistical difference (P>0.05). After CS, the freezing ratio of APP/PS1/tau+Vehicle group mice was significantly lower than that of C57+Vehicle group mice (P<0.01), and was notably increased after B-GOS intervention (P<0.01). Conclusion: B-GOS could reverse the cognitive behavioral impairment of APP/PS1/tau mice and alleviate their depression to a large extent.

Key words: Alzheimer&apos, s disease, Bimuno Galactooligosaccharides, Bifidobacterium, cognitive dysfunction, depression

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