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CJAP ›› 2016, Vol. 32 ›› Issue (2): 112-115.doi: 10.13459/j.cnki.cjap.2016.02.005

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Changes of colonic permeability and its correlation with TNF-α, NF-κB p65 in ulceration colitis mice

HUANG Xun-ru1, WANG Cheng-dang1, WANG Rui-xing2, JIAO Hai-xia2   

  1. 1. Department of Gastroenterology, the First Affiliate Hospital, Fujian Medical University, the Digestive Disease Lab of Fujian Medical University, Fujian 350005;
    2. Department of Physiology and Pathophysiology, Fujian Medical University, Fujian 350108, China
  • Received:2015-07-28 Revised:2016-01-28 Online:2016-03-28 Published:2018-06-12
  • Supported by:

Abstract: Objective: To study the changes of colonic permeability and its correlation with TNF-α, NF-κB p65 in indextran sulphate sodium (DSS) -induced ulcerative colitis(UC) of mice. Methods: Forty-eight ICR mice were randomly divided into the control group and the model group. The acute UC model was induced by quantified intragastric administration of 2.5% DSS in mice. The disease activity index(DAI), histopathology scores, colonic permeability, expression of TNF-α, NF-κB p65 in colonic tissue were determined. The change of colonic permeability and its correlation with DAI, TNF-α, NF-κB p65 were analyzed. Results: Compareded with the control group, DAI colonic permeability of colonic tissue,and the expression of TNF-α NF-κB p65 in the model group were increased significantly (P<0.01, P<0.01). The increased colonic permeability correlated with DAI (P<0.01), and the expression of TNF-α(P<0.01), NF-κB p65(P<0.01) changed significantly. Conclusion: The alteration of colonic permeability and increased expression of TNF-α, NF-κB p65 may play important roles in the occurrence and development of UC.

Key words: dextran sulfate sodium, ulcerative colitis, permeability, NF-κB p65, TNF-α, mice

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