Home  About Journal Instructions for Authors Editorial Board Subscribe Advertisement Messages Board Contact Us 中文

CJAP ›› 2016, Vol. 32 ›› Issue (2): 137-141.doi: 10.13459/j.cnki.cjap.2016.02.011

Previous Articles     Next Articles

Effects of VOR on asthmatic BALB/c mice and on immune-activity of Th17 cells

TUO Hai-yan1, REN Yuan1,2, WANG Zhi-wang1,2, CHENG Xiao-li1, LIU Xue-feng1, LI Rong-ke1, WANG Rui-qiong1   

  1. 1. Gansu University of Traditional Chinese Medicine, Lanzhou 730000;
    2. Key Laboratory of Pharmacology and Toxicology for Traditional Chinese Medicine of Gansu Province, Lanzhou 730000, China
  • Received:2015-09-17 Revised:2016-01-25 Online:2016-03-28 Published:2018-06-12
  • Supported by:
    国家自然科学基金项目(81460668);甘肃省自然科学基金项目(1310RJZA086);甘肃中医药大学研究生创新基金项目(2015CX23)

Abstract: Objective: To study the anti-asthmatic effects of Volatile oil of Radix Angelicae Sinensis (VOR, Traditional Chinese Medicine) on asthmatic BALB/c mice and its effect on Th17 cell immuno-activity through IL-17A and RORγt. Methods: After grouping (n=12), the asthmatic BALB/c mice were replicated through injection of ovalbumin (OVA) for sensitization and administration of OVA aerosol for challenge and then, the asthmatic behaviors, respiratory function, lung histopathology as well as levels of IL-17A in serum and retinoid-related orphan receptor gamma t (RORγt) in lung tissue were observed after the action of VOR. Results: VOR could maintain normal growth of body weight in asthmatic mice, improve asthmatic behaviors, respiratory function, lung histopathology and, inhibit over-expression of IL-17A and RORγt (P<0.05, 0.01) at 60, 120, 240 mg/kg doses. The combination of VOR and dexamethasone could bring synergistic effects on growth of body weight and expression of IL-17A and RORγt. Conclusion: VOR has significant effects of anti-asthma and one of the mechanisms is to inhibit immune activity of Th17 cell through relieving over-expression of IL-17 and RORγt. Besides, the combination of VOR and glucocorticoid could bring synergistic effects.

Key words: Volatile oil of Radix Angelicae Sinensis (VOR), BALB/c mice, antiasthma, Th17 cell

Copyright © 2015 CJAP, All Rights Reserved.
Powered by Beijing Magtech Co. Ltd