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CJAP ›› 2016, Vol. 32 ›› Issue (2): 142-145.doi: 10.13459/j.cnki.cjap.2016.02.012

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Effect of Panax NotoginSeng Saponins on motor evoked potentials of spinal cord injured rats with motion function

YANG Hui1, ZHANG Yu1, CHEN Xu-yi2, ZHAO Chang-yu2, WU Hui-li2, XING Ran1, ZHAO Yong-qing2   

  1. 1. Tianjin University of Traditional Chinese Medicine, Tianjin 300073;
    2. The Affiliated Hospital of Logistics College of CAPF, Tianjin 300162, China
  • Received:2015-04-14 Revised:2015-10-08 Online:2016-03-28 Published:2018-06-12
  • Contact: 赵永青,Tel:15022484780;E-mail:yongqing650912@163.com E-mail:yongqing650912@163.com
  • Supported by:
    赵永青,Tel:15022484780;E-mail:yongqing650912@163.com

Abstract: Objective: To investigate the effect of Panax NotoginSeng Saponins(PNS) on functional recovery of rats with spinal cord injury (SCI) after exercise. Methods: SD normal rats were randomly divided into normal control group (Normal) and control group (Sham), spinal cord injury (SCI) and spinal cord injury (SCI) + panax notoginseng saponins group (PNS) (n=8). All rats were given basso beattie bresnahan motor function score (BBB) and motor evoked potentials (MEP) examination to observe rat hind limb motor function recovery before operation and 1,3,7,14,21,28 days after operation. Results: After operation, the BBB scores of Sham group, PNS group, SCI group were lower than that of normal; MEP amplitude was lower than that of normal group; the incubation time was prolonged compared with that in normal group. In PNS group compared with that in the SCI group, BBB scores at 7,14,21 and 28 days was significantly different(P<0.05). There were significant differences in the latency (Lat) and amplitude(Amp) of MEP within PNA subgroups or between the PNS and the SCI groups at 7,14,21,28 days(P<0.05). Conclusion: PNS can promote the recovery of motor function after SCI in rats.

Key words: spinal cord injury, panax notoginseng saponins(Traditional Chinese Medicine), motor evoked potentials, rats

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