Effects of 5-HT1A receptor antagonist on ethanol induced hypothermia and behavioral thermoregulatory response in rats

doi:10.12047/j.cjap.5448.2017.006

Abstract

Abstract: Objective: To observe the effects of 5-HT_1Areceptor antagonist p-MPI on ethanol induced hypothermia and behavioral ther-moregulatory response in rats.Methods: Core temperature and motor activities were monitored in undisturbed male SD rats using radioteleme-try. The behavioral thermoregulatory response and core temperature were monitored in rats using radiotelemetric temperature gradient apparatus. The rats were placed in a temperature gradient that permitted the selection of ambient temperature ranging from 15℃ to 40℃. Effect of ethanol (3 g/kg) and 5-HT_1A receptor antagonist p-MPPI(1 mg/kg) on core temperature, motor activities, and the behavioral thermoregulatory re-sponse were observed in rats.Results: ①Ethanol led to a rapid reduction in core temperature. The hypothermic responses were accompanied with a preference for cooler ambient temperature. ②5-HT_1A receptor antagonist attenuated the hypothermia induced by ethanol, and accompa-nied with a selection for warmer ambient temperature.Conclusion: ①Behavioral thermoregulatory observations suggested that the ethanol could decrease the thermoregulatory set point,because rats treated with ethanol selected cooler ambient temperature facilitates the reduction in core temperature.②5-HT might be involved in ethanol-induced hypothermia and behavioral thermoregulatory response.

Key words: ethanol, hypothermia, rat, behavioral thermoregulation, 5-HT_1A receptor antagonist

YANG Yong-lu, ZAN Wang, BU Shu, LUO Rong, XU Jian-hui. Effects of 5-HT_1A receptor antagonist on ethanol induced hypothermia and behavioral thermoregulatory response in rats[J]. CJAP, 2017, 33(1): 26-30.

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Effects of 5-HT_1A receptor antagonist on ethanol induced hypothermia and behavioral thermoregulatory response in rats

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