Home  About Journal Instructions for Authors Editorial Board Subscribe Advertisement Messages Board Contact Us 中文

CJAP ›› 2018, Vol. 34 ›› Issue (5): 445-449.doi: 10.12047/j.cjap.5688.2018.101

Previous Articles     Next Articles

Effects of aerobic exercise combined with chlorella pyrenoidos of disintegrated cell wall on some indicators of lipid metabolism in rats with high-fat diet

ZHANG Jing1,2, MIAO Gang1, CAO Jian-min3, ZHOU Hai-tao1,2, NIU Yan-long4, ZHANG Yue1, REN Yi1, BAO Xin-yue1, XING Ya-wen1   

  1. 1. Biochemical Engineering College of Beijing Union University, Beijing 100023;
    2. Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191;
    3. Beijing Sport University, Beijing 100084;
    4. Gannan Medical University, Ganzhou 341000, China
  • Received:2018-03-26 Revised:2018-09-25 Online:2018-09-28 Published:2019-02-21
  • Supported by:
    北京市朝阳区协同创新项目(CYXC1508);北京联合大学“启明星”大学生科技创新项目(201711417SJ036)

Abstract: Objective: To study the effects of aerobic exercise combined with chlorella pyrenoidos of disintegrated cell wall on the lipid metabolism in rats with high-fat diet. Methods: Fifty-five male Wistar rats were subjected to adaptive feeding for 4 days and weight-free swimming training for 3 days, 20 min/d. After eliminating 5 rats that were not suitable for swimming training, the other rats were randomly divided into 5 groups according to their body weight:control group (C group), high fat diet group (H group), high-fat diet + chlorella group(HC group), high fat diet + aerobic exercise group (HM group), high fat diet + chlorella + aerobic exercise group (HMC group), 10 in each group. The HM and HMC group were subjected to 60 min/d swimming training for 6 weeks with non-weight-bearing. Group C were fed regular diet. The other groups were fed with high-fat diet, the rats in group HC and HMC were intragastrically treated with chlorella pyrenoidos of disintegrated cell wall at the dose of 3.9 g/(kg·d), the volume was 5 ml/kg, and the other groups are given equivalent saline. The Lee's index and biochemical indexes of blood and liver were measured after 6 weeks. Results: Compared with group C, Lee's index, serum levels of free fatty acids(FFA), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-c), liver FFA and interleukin-10 (IL-10) were increased significantly (P<0.01), the serum level of high-density lipoprotein cholesterol (HDL-c) was decreased significantly (P<0.01) in group H. Compared with group H, Lee's index, serum FFA, IL-6, TNF-α, TC, TG, LDL-c, liver FFA and IL-10 were decreased significantly (P<0.05 or P<0.01), serum level of HDL-c was increased significantly (P<0.05 or P<0.01) in group HC, HM and HMC. Compared with group HC and HM, Lee's index, serum FFA, IL-6, TNF-α, TC, TG, LDL-c, liver FFA and IL-10 were decreased significantly (P<0.05), serum level of HDL-c was increased significantly (P<0.05) in group HMC. Conclusion: Aerobic exercise and chlorella pyrenoidos of disintegrated cell wall can improve lipid metabolism in rats with high-fat diet and reduce the lipid toxicity caused by obesity. Joint intervention is more effective than single intervention.

Key words: aerobic exercise, chlorella pyrenoidos of disintegrated cell wall, high-fat diet, rat, lipid metabolism

Contact Email:editor@cjap.ac.cn
Copyright © 2015 CJAP, All Rights Reserved.
Powered by Beijing Magtech Co. Ltd