The effect of transcranial direct current stimulation on dysfunction of bilateral posterior cingulate cortex after sleep deprivation: a preliminary study

doi:10.12047/j.cjap.5886.2020.023

CJAP ›› 2020, Vol. 36 ›› Issue (2): 101-105.doi: 10.12047/j.cjap.5886.2020.023

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The effect of transcranial direct current stimulation on dysfunction of bilateral posterior cingulate cortex after sleep deprivation: a preliminary study

MENG Qing-qing^1,2, LI Ji-yuan³, GUO Da-long⁴, SHAO Yong-cong⁵, ZHANG Xi^1△

1. Department of Geriatric Neurology, Sleep Medicine Research Center, the General Hospital of the People's Liberation Army, Beijing 100853;
2. Departmengt of Health Administration of the Central Military Commission, Beijing 100034;
3. Department of MRI, Beijing Shijitan Hospital Capital Medical University, Beijing 100038;
4. Air Force Institute of Aviation Medicine, Aviation Medical Engineering Research Center, Beijing 100037;
5. Beijing Institute of Basic Medical Sciences, Cognitive and Mental Health Research Center, Beijing 100850, China

Online:2020-03-28 Published:2020-07-31

Abstract

Abstract: Objective: To investigate the effects of transcranial direct current stimulation (tDCS) on the disturbance of brain network dysfunction after sleep deprivation (SD). Methods: The experimental design of self-control was used in the study. All 16 subjects received 2 times of 24 h SD with an interval of 3 weeks. After the first normal sleep, 24 h SD and transcranial electrical stimulation (true or false stimulation) intervention (the current magnitude of true and false stimulation was 1 mA, and the action time was 20 min and 2 s, respectively. The intervention experiment lasted for 20 min. ) and the resting magnetic resonance imaging data were collected after the second transcranial electrical stimulation (sham or true stimulation). The resting fMRI data were collected as baseline before SD, the bilateral posterior cingulate cortex in the default mode network was selected as the seed point, and the functional connectivity between the seed points and the whole brain was calculated. Results: Compared with the rest wakefulness, the functional connectivity among bilateral posterior cingulate cortex, bilateral thalamus and hippocampus was increased (P＜0. 01), but connected with the right precuneus, bilateral insula was decreased after 24 h SD (P＜0. 01). Compared with the sham tDCS group, the functional connectivity between left posterior cingulate cortex seed point and right precuneus of tDCS group was increased (P＜0. 01); but decreased with the bilateral thalamus, insula and right cerebral cortex (P＜0. 01). There was a decrease in the functional connectivity among the right posterior cingulate cortex and the bilateral thalamus, right insula, and cerebral cortex(P＜0. 01). Conclusion: 24-hours sleep deprivation can cause functional connection disorder of bilateral posterior cingulate gyrus, and transcranial electrical stimulation can improve the functional connection disorder after sleep deprivation to some extent.

Key words: transcranial direct current stimulation, sleep deprivation, resting state function magnetic resonance imaging, functional connectivity, posterior cingulate cortex

CLC Number:

R445.2

MENG Qing-qing, LI Ji-yuan, GUO Da-long, SHAO Yong-cong, ZHANG Xi. The effect of transcranial direct current stimulation on dysfunction of bilateral posterior cingulate cortex after sleep deprivation: a preliminary study[J]. CJAP, 2020, 36(2): 101-105.

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The effect of transcranial direct current stimulation on dysfunction of bilateral posterior cingulate cortex after sleep deprivation: a preliminary study

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