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Correlation between Expression of LIF / Apelin mRNA in placentatissue of hypertensive patients during pregnancy and perinatal outcome |
GAO Fang, SUN Sufen, LI Zhihong,ZHANG Haihong,CHENG Xiaohan |
Tangshan Union Hospital, Tangshan, Hebei 063000, China |
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Abstract Objective To investigate the correlations between the expression of leukaemia inhibitory factor (LIF) and Apelin mRNA in placenta tissue of patients with hypertension in pregnancy and the perinatal outcome.Methods 160 cases of patients with hypertension in pregnancy trated at our hospital from January 2012 to December 2014 were collected while another 80 cases of healthy pregnant women were collected during the same period. The expressions of LIF and Apelin mRNA were detected by real-time fluorescence quantitative PCR (qPCR). Logistic regression analysis was used to analyze the correlation between the levels of LIF/Apelin mRNA and hypertension in pregnancy.Results The expression of LIF and Apelin mRNA in placenta tissue of pregnant women with gestational hypertension group was lower than that of healthy pregnant women group(P<0.05). The correlation between the expression level of LIF/Apelin mRNA and the perinatal outcome was statistically significant (P<0.05). The maximum likelihood estimates and OR values were less than 0. The correlation coefficient of LIF/Apelin mRNA average expression score and mean birth weight and average neonatal score ranged from 0.721 to0.836.Conclusion The expression of LIF/ Apelin mRNA in placenta tissue of patients with hypertension in pregnancy is negatively correlated with the adverse perinatal outcome.
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Received: 27 January 2016
Published: 05 January 2017
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