Abstract: Objective:To discuss the modulating effects of shenmai (Traditional Chinese Medicine) injection on blood lipid in hyperlipidemia rats through observing the serum lipid level and a series of related biochemical indexes in hyperlipidemia rat model. Methods:A total of 30 male SD rats of SPF grade were purchased and fed with basic feed for 1 week to adapt the environment. Then the rats were randomly divided into the following groups(n=10):control group, model control group, shenmai injection group. Control group was fed basal diet; the latter two groups were fed high fat diet,the body weight of all the animals was measured each week. For shenmai injection group, the rats were fed with shenmai injection (10 ml/kg) twice a day for 45 consecutive days through oral administration. The effects of shenmai injection on body weight, serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), super oxide dismutase (SOD), glutathione peroxidase(GSH-Px), malondialdehyde (MDA), the activities of lipoprotein lipase(LPL) and hepatic lipase (HL) in hyperlipidemia rats were detected. Results:Body weight, serum of TC, TG, LDL-C, HDL-C, and MDA levels in model control group were significantly higher(P<0.01), while serum of HDL-C, SOD, GSH-Px, LPL, and HL levels were significantly lower than those of control group(P<0.01). Body weight, serum of TC, TG, LDL-C, HDL-C, and MDA levels in shenmai injection group were significantly lower(P<0.01), while serum of HDL-C, SOD, GSH-Px, LPL, and HL levels were significantly higher than those of model group(P<0.05, P<0.01). Conclusion:Shenmai injection has a significant effect of modulating blood lipid and antioxidant function on hyperlipidemia rats.

Key words: hyperlipidemia, superoxide dismutase, glutathione peroxidase, malondialdehyde, lipoprotein lipase, hepatic lipase