%A ZHOU Ben-mei, GUO Xing-ming, ZHENG Yi-neng, LI Hong-quan
%T Changes of some biochemical markers and cardiac function in New Zealand rabbits with chronic heart failure
%0 Journal Article
%D 2018
%J CJAP
%R 10.12047/j.cjap.5534.2018.019
%P 74-77
%V 34
%N 1
%U {http://manu37.magtech.com.cn/Jwk_jsyxkx/cjap/CN/abstract/article_148189.shtml}
%8 2018-01-28
%X Objective: This article investigated the changes of some biochemical markers and cardiac function in chronic heart failure (CHF), and provided the basis for the diagnosis of CHF.Methods: New Zealand rabbit CHF model was established using adriamycin (ADR). Twenty New Zealand rabbits were randomly divided into model group (n=15) and control group (n=5), injected with ADR and saline solution via the ear vein respectively, 2 times a week, lasting for 8 weeks. After that, myocardial enzymes, carotid artery pressure, echocardiogram (ECG) and phonocardiogram (PCG) of all New Zealand rabbits were detected and recorded.Results: Compared with control group, all parameters of the model group were changed significantly (P<0.05).Conclusion: CHF leads to myocardial damage in New Zealand rabbits, decreased systolic and diastolic function, cardiac reserve index can be used to assess cardiac function.