%A ZHOU Ben-mei, GUO Xing-ming, ZHENG Yi-neng, LI Hong-quan %T Changes of some biochemical markers and cardiac function in New Zealand rabbits with chronic heart failure %0 Journal Article %D 2018 %J CJAP %R 10.12047/j.cjap.5534.2018.019 %P 74-77 %V 34 %N 1 %U {http://manu37.magtech.com.cn/Jwk_jsyxkx/cjap/CN/abstract/article_148189.shtml} %8 2018-01-28 %X Objective: This article investigated the changes of some biochemical markers and cardiac function in chronic heart failure (CHF), and provided the basis for the diagnosis of CHF.Methods: New Zealand rabbit CHF model was established using adriamycin (ADR). Twenty New Zealand rabbits were randomly divided into model group (n=15) and control group (n=5), injected with ADR and saline solution via the ear vein respectively, 2 times a week, lasting for 8 weeks. After that, myocardial enzymes, carotid artery pressure, echocardiogram (ECG) and phonocardiogram (PCG) of all New Zealand rabbits were detected and recorded.Results: Compared with control group, all parameters of the model group were changed significantly (P<0.05).Conclusion: CHF leads to myocardial damage in New Zealand rabbits, decreased systolic and diastolic function, cardiac reserve index can be used to assess cardiac function.