%A GAO Wei, WANG Nan, QIAO Hu
%T The effects of 5-HT1B receptor subtypes on motor behaviors mediated by cerebellar fastigial nucleus
%0 Journal Article
%D 2016
%J CJAP
%R 10.13459/j.cnki.cjap.2016.06.014
%P 550-554
%V 32
%N 6
%U {http://manu37.magtech.com.cn/Jwk_jsyxkx/cjap/CN/abstract/article_148196.shtml}
%8 2016-11-28
%X Objective: To investigate the effects of the serotonergic nervous system on motor behaviors mediated by cerebellar fastigial nucleus (FN). Methods: In this experiment, the main methods are whole-cell patch clamp recording and Rota-rod test. Results: We found that the excitatory synaptic transmission was enhanced in the cerebella FN after blocking 5-hydroxytryptamine,(5-HT)receptor. Microinjection of 5-HT into FNs remarkably promoted motor performances on Rota-rod, which could be reversed by microinjection of 5-HT receptor antagonist SB224289. Conclusion: These results suggest that the 5-HT can suppress cerebellar FN excitatory synaptic transmission via 5-HT1B receptors, thereby modulate the activity of cerebellar nuclear neurons circuitry, and subsequently influence the cerebellum-mediated ongoing motor balance and coordination.