Abstract：Objective To observe the effect of Niaoduqing (NDQ) combined with compound α-keto acid (CAA) tablets on calcium (Ca)-phosphorus (P) metabolism in patients with maintenance hemodialysis.Methods A total of 188 patients with end-stage renal disease (ESRD) during September 2013 and December 2014 were randomly divided into control group (routine therapy including maintenance hemodialysis and symptomatic treatment,n= 47),and three treatment group (drug intervention based routine therapy for 6 months, each n=47):NDQ group(5g NDQ tid),CAA group(5 tablets CAA tid),NDQ+CAA group(5g NDQ tid plus 5 tablets CAA tid).The indexes of Ca-P metabolism and serum creatinine(Cr),blood urea nitrogen(BUN),and albumn(Alb) were detected before and after treatment.Results The indexes of Ca-P metabolism, Cr,BUN, and Alb had no significant change after treatment in control group (P>0.05).NDQ and CAA alone showed effects in decreasing the level of serum P,Ca-P product and PTH after treatment.Serum P and PTH decreased significantly after treatment compared to before treatment in NDQ+CAA group,and which was most effective among 4 groups.Serum Cr,BUN, Alb had no significant change after treatment in NDQ group and CAA group.The effects of decreasing BUN and increasing Alb were better in NDQ+CAA group than other three groups(P<0.05).Conclusion NDQ combined with CAA can play a role in regulating Ca-P metabolism of ESRD patients,decrease BUN,and improve nutritional status.The combination of NDQ with CAA has better effect than use alone.
刘乃全,孙广萍. 尿毒清联合复方α－酮酸片对维持性血液透析患者钙磷代谢的影响[J]. 解放军预防医学杂志, 2016, 34(2): 172-174.
LIU Naiquan,SUN Guangping. Effect of Niaoduqing Combined with Compound Alpha-keto Acid Tablets on Calcium-phosphorus Metabolism in Patients with Maintenance Hemodialysis. Journal of Preventive Medicine of Chinese People's Liberation Army, 2016, 34(2): 172-174.
2016, Vol. 34 
