中医配合磷酸肌酸钠治疗一氧化碳中毒的疗效分析

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摘要目的分析与评价中医配合磷酸肌酸钠在治疗一氧化碳中毒过程中的疗效，为一氧化碳中毒的治疗提供指导。方法选择2012年6月至2014年12月该院收治的120例一氧化碳中毒患者为研究对象，按照治疗方式不同分为观察组和对照组，每组各60例。对照组患者采用高压氧等常规治疗，观察组患者加用中医药方配合磷酸肌酸钠治疗。比较2组患者治疗前后HDS评分、P300潜伏期、神经功能损伤评分和心肌损伤标志物变化，评价2组患者疗效差异。结果治疗后观察组患者与对照组相比HDS评分明显升高，P300潜伏期明显缩短(P＜0.05)，NIHSS评分和血清cTNI、CK-MB、IMA水平明显降低(P＜0.05)，观察组患者的治疗效果显著优于对照组(P＜0.05)。结论中医配合磷酸肌酸钠治疗一氧化碳中毒能够有效改善心脏和脑组织缺氧状态，减轻神经功能损伤，疗效显著优于单一高压氧常规治疗。

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关键词 ：一氧化碳中毒, 高压氧, 中药, 磷酸肌酸钠, 治疗效果

Abstract：Objective To evaluate the therapeutic effect of hyperbaric oxygen combined with traditional Chinese medicine and creatine phosphate sodium on carbon monoxide poisoning.Methods, A total of 120 carbon monoxide poisoning patients in our hospital from June 2012 to December 2014 were divided into the observation group (n=60) and control group (n=60). The patients of control group received hyperbaric oxygen therapy, while those of observation group were treated with traditional Chinese medicine and creatine phosphate sodium plus hyperbaric oxygen therapy. The HDS score, P300 latency, neurologic impairment score and myocardial injury markers were compared between the two groups before and after treatment.Results After treatment, the HDS score of the observation group was significantly higher than that of the control group (P＜0.05), but the latency of P300 was significantly shortened (P＜0.05). NIHSS score and serum cTNI, IMA, CK-MB levels in the observation group were significantly lower than those in the control group (P＜0.05). The therapeutic effect of observation group was significantly better than that of control group (P＜0.05).Conclusion Hyperbaric oxygen combined with traditional Chinese medicine and creatine phosphate sodium can effectively protect myocardium and neurons during the treatment of patients with carbon monoxide poisoning. The therapeutic effect is significantly better than that of hyperbaric oxygen therapy alone.

Key words： carbon monoxide poisoning hyperbaric oxygen traditional Chinese medicine with creatine phosphate sodium therapeutic effect

出版日期: 2016-09-14

基金资助:河北省卫生厅重点科技研究计划(No.20150553)

作者简介: 李俊坤(1967-)，女，大学本科，副主任医师。从事磷酸肌酸钠治疗性一氧化碳中毒研究工作。

引用本文:

李俊坤，赵向辉，刘育慧，梁俊争，周红梅，李春红，宋雪云，刘旭静，张文缙. 中医配合磷酸肌酸钠治疗一氧化碳中毒的疗效分析[J]. 解放军预防医学杂志, 2016, 34(4): 498-500.
LI Junkun, ZHAO Xianghui, LIU Yuhui, LIANG Junzheng, ZHOU Hongmei, LI Chunhong, SONG Xueyun, LIU Xujing, ZHANG Wenjin. Therapeutic Effect of Hyperbaric Oxygen Combined with Traditional Chinese Medicine plus Creatine Phosphate Sodium on Carbon Monoxide Poisoning. Journal of Preventive Medicine of Chinese People's Liberation Army, 2016, 34(4): 498-500.

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http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/CN/ 或 http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/CN/Y2016/V34/I4/498

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