CRF系统的环境有害因素致神经系统效应研究进展

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摘要长期暴露于环境有害因素中可对神经系统发育和学习记忆、情感及行为等神经功能方面造成不利影响，促肾上腺皮质激素释放激素(CRF)是近年来研究发现在神经系统效应调节方面发挥重要作用的一种内源性神经肽，作用的发挥主要通过其G-蛋白受体实现。因此，文章就CRF及其受体系统在环境有害因素神经系统效应方面的研究进展进行了简要综述。

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关键词 ：促肾上腺皮质激素释放激素, 促肾上腺皮质激素释放激素受体, 环境有害因素, 神经系统

Abstract：Long-term environmental hazard exposure can result in varying degrees of impact on the development of the central nervous system(CNS) and on other functions, such as learning and memory, emotion and behavior. Corticotropin- releasing factor (CRF) is an endogenous neuropeptide found in recent years, which plays an important role in regulating the CNS need by binding to its G- protein receptors. This paper aims to review the effects of CRF and its receptor system on CNS injuries induced by environmental hazards.

Key words： corticotropin- releasing factor corticotropin- releasing factor receptors environmental hazard central nervous system

出版日期: 2016-09-14

基金资助:天津市应用基础与前沿计划资助面上项目(No.14JCYBJC24700)

通讯作者: 13075308745@163.com;iamcuib@sina.com

作者简介: 盖志辉(1987-)，男，在读硕士研究生。从事职业病防治研究。

引用本文:

盖志辉，王瑞，崔博. CRF系统的环境有害因素致神经系统效应研究进展[J]. 解放军预防医学杂志, 2016, 34(4): 580-583.
GAI Zhihui, WANG Rui, CUI Bo. CRF System Involved in Environmental Hazard-Induced Changes in the CNS. Journal of Preventive Medicine of Chinese People's Liberation Army, 2016, 34(4): 580-583.

链接本文:

http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/CN/ 或 http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/CN/Y2016/V34/I4/580

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