原发性膝骨关节炎患者骨质疏松及维生素D缺乏症患病率研究

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摘要目的探讨正常人群与原发性膝骨关节炎(OA)患者骨质疏松症(OP)及维生素D缺乏症患病情况。方法选择某医院收治的原发性OA 98例,选择同期健康人108例作为正常对照组。对两组进行双能力线吸收法(DXA)扫描观察骨密度水平,采集血液样本进行血清维生素D测定。分析骨密度水平、血清维生素D₃水平与原发性OA的相关性。结果骨密度水平与原发性OA显著相关,血清维生素D₃水平与OA显著相关(P<0.05)。血清维生素D₃水平与年龄间无相关性(P>0.05),与性别、骨密度存在显著相关性(P<0.01)。结论 OP在正常人群和OA患者中患病率较高,维生素D₃缺乏症在OA患者中发病率较高,且与骨密度相关。

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关键词 ：膝骨关节炎, 骨质疏松症, 维生素D₃, 现患率

Abstract：Objective To observe the prevalence of osteoporosis and hypovitaminosis D in general populations and in patients with primary osteoarthritis (OA). Methods A total of 90 patients with primary knee OA were studied from Tongchuan Mining Central Hospital, while another 108 healthy people were used as controls. Bone mineral density was observed by DXA, and serum vitamin D was detected. The relation between BMD, vitamin D3 and primary OA was observed. Results BMD was significantly correlated with primary OA andthe level of serum vitamin D3 with osteoarthritis(P<0.05). While the age of patients was significantly correlated with both BMD and knee OA, the level o serum vitamin D3 was not related to age(P>0.05), but significantly related to gender and BMD(P<0.01). Conclusion Osteoporosis is prevalent both in general populations and patients with knee osteoarthritis. The morbidity of hypovitaminosis D3 is high in OA patients and is related to BMD.

Key words： osteoarthritis osteoporosis vitamin D3 prevalence rate

出版日期: 2016-11-02

基金资助:陕西省自然科学基金资助项目(No.2013JM4012

引用本文:

于乐. 原发性膝骨关节炎患者骨质疏松及维生素D缺乏症患病率研究[J]. 解放军预防医学杂志, 2016, 34(5): 704-705.
YU Le. Prevalence of Osteoporosis and Hypovitaminosis D in Patients with Primary Knee Osteoarthritis. Journal of Preventive Medicine of Chinese People's Liberation Army, 2016, 34(5): 704-705.

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http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/CN/ 或 http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/CN/Y2016/V34/I5/704

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