血清血管内皮生长因子和骨桥蛋白水平对膀胱癌淋巴转移的影响

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摘要目的探讨膀胱癌患者血清血管内皮生长因子(VEGF)、骨桥蛋白(OPN)水平对淋巴转移的影响。方法选择2012年1月-2015年1月在某院泌尿外科接受根治性全膀胱切除术的29例膀胱癌患者,根据术后淋巴结转移情况分为淋巴结阴性组(14例)及淋巴结阳性组(15例),选择同期健康人群30例,对各组血清VEGF、OPN及尿肿瘤标志物进行检测。结果淋巴结阴性组和淋巴结阳性组VEGF、OPN、核基质蛋白22(NMP22)、角蛋白19可溶性片段(CYFR21-1)、膀胱肿瘤抗原(BTA)均高于对照组,且淋巴结阳性组高于淋巴结阴性组(P<0.05)。VEGF与NMP22、CYFR21-1、BTA呈显著正相关,OPN与NMP22呈显著正相关(P<0.05)。结论 VEGF及OPN水平升高是导致膀胱癌淋巴转移的重要因素,该过程与尿液肿瘤标志物升高密切相关。

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关键词 ：膀胱癌, 淋巴转移, 血管内皮生长因子, 骨桥蛋白

Abstract：Objective To investigate the effect of serum vascular endothelial growth factor (VEGF) and osteopontin (OPN) on lymph node metastasis in patients with bladder cancer. Methods A total of 29 bladder cancer patients treated by radical cystectomy between January 2012 and January 2015 were enrolled, including 14 cases of lymph node metastasis and 15 cases of non-lymph node metastasis. Thirty healthy people were enrolled as control group. Serum VEGF and OPN and urine tumor markers were detected. Results VEGF, OPN, nuclear matrix protein22 (NMP22), CYFR21-1 and BTA in bladder cancer patients were all higher than those in control group (P<0.05). All the indicators in patients with lymph node metastasis were higher than those in patients without lymph node metastasis(P<0.05). VEGF was significantly and positively correlated with NMP22, CYFR21-1 and bladder tumor antigen (BTA) (P<0.05),while OPN was significantly and positively correlated with NMP22 (P<0.05) . Conclusion Elevated levels of VEGF and OPN are important factors leading to bladder cancer lymph node metastasis. The process is closely related to the increase of urine tumor markers.

Key words： bladder cancer lymph node metastasis vascular endothelial growth factor osteopontin

出版日期: 2016-11-02

基金资助:国家自然科学基金资助项目(No.81471446)

通讯作者: 78402275@qq.com

引用本文:

闫小晨, 张连栋. 血清血管内皮生长因子和骨桥蛋白水平对膀胱癌淋巴转移的影响[J]. 解放军预防医学杂志, 2016, 34(5): 715-717.
YAN Xiaochen, ZHANG liandong. Effect of Serum VEGF and OPN on Lymph Node Metastasis in Bladder Cancer Patients. Journal of Preventive Medicine of Chinese People's Liberation Army, 2016, 34(5): 715-717.

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