Abstract：Objective To study the correlations between non-small cell lung cancer and life events, psychosocial stress factors such as emotional state in order to contribute to the prevention and treatment of non-small cell lung cancer.Methods On the basis of case - control study, forty-five pathologically diagnosed cases of non-small cell lung cancer were selected as the observation group while another forty-five cases of non-small cell lung cancer with benign conditions as were in the control group.Psychosocial stress questionnaires were used to collect information on their life events and emotional response.The levels of anxiety in each group were evaluated by the self-assessment lists of anxiety (SAS).Results Multiariable logistic regression analysis showed that economic plight(OR=3.143), worry about children's future(OR=7.721), depression(OR=6.122), and despair(OR=18.215) were risk factors for non-small cell lung cancer while a pleasant emotional state (OR=0.043) was a protective factor.Compared with the control group, the level of anxiety was quite high among patients of the observation group, and the difference was statistically significant (P<0.05).Conclusion Some negative life events and negative emotions are associated with the onset of non-small cell lung cancer.A good mood can reduce the risk of non-small cell lung cancer to some certain extent.
孟凡影, 孙惠昕. 非小细胞肺癌与心理社会应激因素的关系[J]. 解放军预防医学杂志, 2016, 34(6): 843-845.
MENG Fanying, SUN Huixin. Relationships between Non-small Cell Lung Cancer and Psychosocial Risk Factors. Journal of Preventive Medicine of Chinese People's Liberation Army, 2016, 34(6): 843-845.
BUCKLEY M M,O'MAHONY S M,O'MALLEY D.Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome[J].World J Gastroenterol,2014,20(27):8846.
[2]
SMITH H R.Depression in cancer patients:Pathogenesis, implications and treatment (Review)[J].Oncol Lett,2015,9(4):1509.
[3]
GINZBURG K,WRENSCH M,RICE T,et al.Breast cancer and psychosocial factors:early stressful life events,social support, and well-being[J].Psychosomatics,2008,49(5):407.
[4]
NIU Z M,LIANG C S,YU M,Psychosocial response and symptom burden for male smokers withlung cancer[J].Asian Pac J Cancer Prev,2014,15(1):309.
[5]
姜乾金.心理社会应激因素的综合评估初探[J].中国行为医学科学,1998,7(03):182.
[6]
MIN J A,YOON S,LEE C U,et al.Psychological resilience contributes to low emotional distress in cancer patients[J].Support Care Cancer,2013,21(9):2469.
[7]
HAN X,LIN C C,LI C,et al.Association between serious psychological distress and health care use and expenditures bycancer history[J].Cancer,2015,15:121(4):614.
[8]
BIONDI M,COSTANTINI A,PARISI A.Can loss and grief activate latent neoplasia?A clinical case of possible interaction between genetic risk and stress in breast cancer[J].Psychother Psychosom,1996,65(2):102.
[9]
RONG C,JIANG H F,ZHANG R W,et al.Factors associated with relapse among heroin addicts: evidence from a two-year community-based follow-up study in China[J].Int J Environ Res Public Health,2016,13(2):343.
[10]
BIERHAUS A,WOLF J,ANDRASSY M,et al.A mechanism converting psychosocial stress into mononuclear cell activation[J].ProcNatl Acad Sci U S A,2003,100(4):1920.
[11]
JEHN C F,KUEHNHARDT D,BARTHOLOMAE A,et al.Biomarkers of depression in cancer patients[J].Cancer,2006,107(11):2723.
[12]
CHOJU M,OKAMURA H.Partnership in psycho-social group intervention for cancer patients: factors to rreating group dynamics[J].Yonago Acta Med,2015,58(1):45.
[13]
O'CONNOR R M,MOLONEY R D,GLENNON J.Enhancing glutamatergic transmission during adolescence reverses early-life stress-induced deficits in the rewarding effects of cocaine in rats[J].Neuropharmacology,2015,99(34):168.
[14]
DANTZER R,O'CONNOR J C,FREUND G G,et al.From inflammation to sickness and depression:when the immune system subjugates the brain[J].Nat Rev Neurosci,2008,9(1):46.
[15]
FINCH L E,TOMIYAMA A J.Comfort eating,psychological stress,and depressive symptoms in young adult women[J].Appetite,2015,95(3):239.
[16]
KLAININ-YOBAS P,IGNACIO J,HE HG.Effects of a stress-management program for inpatients with mental disorders:A feasibility study[J].Biol Res Nurs,2015,16(2):353.
[17]
SHIN J A,KOSIBA J D,TRAEGER L D.Yspnea and panic among patients with newly diagnosed non-small cell lung cancer[J].J Pain Symptom Manage,2014,48(3):465.
[18]
LITHOXOPOULOU H,ZAROGOULIDIS K,BSOTANTZOPOULOU S.Monitoring changes in quality of life in patients with lung cancer by using specialised questionnaires:implications for clinical practice[J].Support Care Cancer,2014,22(8):2177.
[19]
BROWER V.Mechanistic research illuminating connection among depression, stress, and survival[J].J Natl Cancer Inst,2014,106(3):69.
[20]
LIAO Y C,SHUN S C,LIAO W Y.Quality of life and related factors in patients with newly diagnosed advanced lung cancer:a longitudinal study[J].Oncol Nurs Forum,2014,41(2):44.
2016, Vol. 34 
