颈动脉粥样硬化和血管内皮功能对冠心病临床诊断的预警价值

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摘要目的进一步研究冠心病与颈动脉粥样硬化及血管内皮舒张功能的相关性。方法随机选择101例体检人群,分别进行双侧颈动脉多普勒高频超声、依赖性血管内皮功能( Dependent Vasular Endothelial Function)及32层螺旋CT行冠状动脉造影检查,并根据影像学检查结果,同时测定所有受检者的生化指标,包括三酰甘油三酯(TG) 、总胆固醇(TC) 、低密度脂蛋白(LDL-C) 、空腹血糖(FBG)水平。将受检者分为冠心病( Coronary Heart Disease, CHD,n=53)组和非 CHD(n=48)组,对其结果进行比较和分析。结果 CHD组颈内动脉内-中膜厚度(IMT)显著高于非CHD组(P＜0.05);CHD组血管内皮舒张功能(EDD)显著低于非 CHD组(P＜0.05)。结论颈动脉粥样硬化与血管内皮功能可预测冠心病的发生,可作为监测和评估冠心病的指标。

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关键词 ：颈动脉粥样硬化, 依赖性血管内皮功能, 冠心病, 预警价值

Abstract：Objective To further study the correlations between coronary heart disease (CHD), carotid atherosclerosis and vascular endothelial diastolic functions.Methods 101 subjects undergoing health checkups were randomly selected, who were examined by bilateral carotid high-frequence color Doppler ultrasonography, endothelial dependent vasodilation tests, and 32-slice CT coronary angiography. Such biochemical indicators as three acid triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL-C), and fasting blood glucose levels (FBG) were measured in all the subjects, who were divided into CHD group and non-CHD group before the results of examinations were compared and analyzed.Results The carotid artery intima media thickness(IMT)) in CHD group was significantly higher than in non-CHD group (P<0.05) while EDDwas significantly lower in CHD group than in non-CHD group(P<0.05).Conclusion Carotid atherosclerosis and endothelial functions can predict the occurrence of coronary heart disease.

Key words： carotid atherosclerosis endothelial dependent vasodilation coronary heart disease value of early warning

收稿日期: 2016-01-27 出版日期: 2017-01-05

通讯作者: qyhui4089@163.com

引用本文:

黄喜顺, 王义涛, 郑璇, 邱耀辉. 颈动脉粥样硬化和血管内皮功能对冠心病临床诊断的预警价值[J]. 解放军预防医学杂志, 2016, 34(6): 851-853.
HUANG Xishun, WANG Yitao, ZHENG Xuan, QIU Yaohui. Value of Early Warning of Carotid Atherosclerosis and Vascular Endothelial Function in Clinical Diagnosis of Coronary Artery Diseases. Journal of Preventive Medicine of Chinese People's Liberation Army, 2016, 34(6): 851-853.

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http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/CN/ 或 http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/CN/Y2016/V34/I6/851

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