Abstract：Objective To investigate and analyze the relationships between the expression of uPA and PAI-1 and breast cancer and its prognosis.Methods Between March 2012 and May 2014, 82 cases of breast cancer and 42 cases of benign breast tumor were selected in our hospital. The expression levels of uPA and PAI-1 were detected in both groups of patients, and the correlation between the expression level and breast cancer was analyzed. The cases of breast cancer included 27 cases of recurrence, 55 cases without recurrence, or alternatively 24 cases without metastasis, 58 cases without metastasis. The relationships between the positive expression rate of uPA and PAI-1 and prognosis of the patients after treatment was analyzed.Results The positive expression rate of uPA and PAI-1 in breast cancer group was higher than that in benign breast tumor group (P＜0.05). The positive expression rate of PAI-1 and uPA in breast cancers with recurrence or metastasis was higher than in those without recurrence or metastasis(P＜0.05). Logistic regression analysis showed that OR values of uPA and PAI-1 in breast cancer, breast cancer with recurrence or metastasis were above zero.Conclusion Expressions of PAI-1 and uPA are correlated with breast cancer and its prognosis.
王丽，杨帆，孔祥顺，刘运江，刘登湘. uPA、PAI-1表达与乳腺癌及预后的相关性分析[J]. 解放军预防医学杂志, 2016, 34(4): 528-530.
WAGN Li, YANG Fan, KONG Xiangshun, LIU Yunjiang, LIU Dengxiang. Correlations of Expression of uPA, PAI-1 with Breast Cancer and Its Prognosis. Journal of Preventive Medicine of Chinese People's Liberation Army, 2016, 34(4): 528-530.
(1) HARBCCK N,SCHMITT M,KATCS R E.Clinical utility of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 determination in primary breast cancer tissue for individualized therapy concepts(J).Clin Breast Cancer,2012,3(3): 196. (2) 王素霞.uPA在乳腺癌组织中的表达及临床意义(J).贵阳医学院学报,2014,39(6):887. (3) JANICKC F,PRCCHTL A,THOMSSEN C.Randomized adjuvant chemotherapy trial in high risk, lymph node negative breast cancer patients identified by urokinase-type plasminogen activator and plasminogen activator inhibitor type 1(J).J Natl Cancer Inst,2011,93(12):913. (4) 王亚丽.妊娠相关乳腺癌的影像学征象及临床病理分析(J).现代中西医结合杂志,2014,23(35):3929. (5) VISVADER J E,LINDEMAN G J.Cancer stem cells in solid tumours:accumulating evidence and unresolved questions(J).Nat Rev Cancer,2008,8(10):755. (6) 赵瑞振,张炜,张黎英,等.老年乳腺癌患者的临床病理特点及其辅助治疗模式的研究(J).现代中西医结合杂志,2015,24(6):656. (7) 王丽,杨帆,孔祥顺,等.uPA、PAI-1组织表达与新辅助化疗治疗乳腺癌疗效及预后的相关性分析(J).解放军医药杂志,2016,28(6):8. (8) 范建,杨华英,孙冬霞,等.uPA和FAK在肝癌组织中的表达及相关性研究(J).现代中西医结合杂志,2013,22(6):589. (9) 董欢,林燕苹,应学翔,等.uPA/PAI-1在乳腺癌中的表达及其临床意义的研究进展(J).复旦学报(医学版),2012,39(6):671. (10) 张淑群,魏媛媛,马一楠,等.uPA 在三阴性乳腺癌组织中的表达及临床意义(J).现代肿瘤医学,2014 (7):1567. (11) 汪青.uPA和PAI-1在乳腺癌血浆中的水平测定及其生物学行为的相关性研究(D).第二军医大学,2010. (12) 宋燕,刘雪凯,张青云.抗体芯片技术检测乳腺癌患者血清中PAI-1的表达(J).中国生物制品学杂志,2014,27(9):1192. (13) 王丽,宋兰英,刘运江.乳腺癌组织uPA和PAI-1表达与临床病理因素相关性的探讨(J).中华肿瘤防治杂志,2009,16(22):1765. (14) 陈旭伟,孙伟,崔世义.uPA、PAI-1的表达和MVD计数与浸润性乳腺癌侵袭性的关系(J).现代生物医学进展,2011,11(12):2307. (15) 张晶,王春妮,戚美,等.二烯丙三硫对乳腺癌MDA-MB-231细胞增殖和侵袭的抑制及对uPA系统的调节(J).山东大学学报:医学版,2012,50(10):61. (16) 谭令,王慧,宋晓丹,等.单-ADP-核糖基转移酶3过表达对人乳腺癌细胞MDA-MB-231增殖、凋亡及侵袭的影响(J).中国生物制品学杂志,2014,27(1):72. (17) 郭莹,罗雅玥,董斌,等.抗人乙酰肝素酶单克隆抗体联合紫杉醇对人乳腺癌细胞增殖、迁移和侵袭的影响(J).肿瘤,2015(6):630. (18) DUFFY M J, MCGOWAN P M, HARBECK N,et al.uPA and PAI-1 as biomarkers in breast cancer: validated for clinical use in level-of-evidence-1 studies(J).Breast Cancer Research Bcr,2014,16(4):1. (19) BELLOCQ J P, LUPORSI E, BARRIèRE J,et al.uPA/PAI-1, Oncotype DX, MammaPrint(?). Prognosis and predictive values for clinical utility in breast cancer management(J).Annales De Pathologie,2014,34(5):349. (20) AKUDUGU J, SERAFIN A, BHM L.Further evaluation of uPA and PAI-1 as biomarkers for prostatic diseases(J).Journal of Cancer Research & Clinical Oncology,2014,141(4):627.
2016, Vol. 34 
