Abstract：Objective To investigate the effects of tight junction of the blood-brain barrier on the glioma invasion ability.Methods 87 cases of neurosurgery glioblastoma patients including grade Ⅰ 29 cases,26 cases of patients with grade Ⅱ ,Ⅲ grade 21 cases ,Ⅳ grade 11 patients were enrolled.Serum levels in patients of S-100,GFAP,MMP-2,TIMP-2 were detected.Results S-100,GFAP in patients with grade Ⅱ compared with Ⅰ appeared significantly higher level(P<0.05),S-100,GFAP of Ⅲ grade patients compared with gradeⅠ,Ⅱ grade were significantly higher(P<0.05),S-100,GFAP of Ⅳ grade compared with gradeⅠ,Ⅱgrade ,grade Ⅲ were significantly(P<0.05).MMP-2 / TIMP-2 in Ⅱ level patients compared with class Ⅰ was significantly higher(P<0.05),MMP-2 and TIMP-2 in Ⅲ grade patients compared with grade Ⅰ were any significant different(P<0.05),MMP-2 / TIMP -2 compared with grade Ⅰ ,grade Ⅱ patients were significantly higher(P<0.05),MMP-2 and TIMP-2 and MMP-2 / TIMP-2 of Ⅳ grade compared with grade Ⅰ ,Ⅱ,Ⅲ were any significant different(P<0.05).S-100,GFAP and MMP-2,MMP-2 / TIMP-2 were significantly correlated(P<0.05),while showing no effects on TIMP-2(P>0.05).Conclusion With the progress of glioma grading ,the tight junction of BBB were destroyed and were closely related to glioma invasion ability.
李 峰. 血脑屏障中MMP-2、TIMP-2水平变化与脑神经胶质瘤侵袭能力的关系[J]. 解放军预防医学杂志, 2016, 34(6): 904-906.
LI Feng. Relationship of Blood MMP-2、TIMP-2 Brain Barrier and Glioma Invasion Ability. Journal of Preventive Medicine of Chinese People's Liberation Army, 2016, 34(6): 904-906.
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