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| Effects of Sitagliptin Combined with Metformin onHyperglycemia Metabolic Syndrome |
| ZHANG Kun, REN Qiaohua, WU Tao, DU Junwen |
| Department of Endocrinology, First Hospital of Shijiazhuang, Shijiazhuang 050000, China. |
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Abstract Objective To investigate the curative effect of sitagliptin combined with metformin in the treatment of hyperglycemia metabolic syndrome.Methods A total of 75 patients with hyperglycemia metabolic syndrome admitted in our hospital from Jan 2013 to Jun 2014 were selected and divided randomly into the observation group (n=37) and control group (n=38). Same diet and exercise plan were given to the two groups. Then the observation group was given sitagliptin and metformin treatment, while the control group was given metformin treatment for 12 weeks. The waist circumference (WC), body mass index (BMI), blood glucose, blood lipid, fasting insulin, serum adiponectin and other biochemical indicators were detected and compared. The steady-state model of insulin resistance index (HOMA-IR) and whole body insulin sensitivity index (WBISI) were calculated.Results After treatment, there were statistically differences (P<0.05) between the two groups in WC, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), 2 h postprandial blood glucose (2 h PG), fasting insulin (FINS), HOMA-IR, WBISI and serum adiponectin; The above indexes of the observation group and control group were both obviously improved, and the improved effect of observation group was significantly better than that of the control group (P<0.05).Conclusion The sitagliptin combined with metformin has better curative effect in treatment of hyperglycemia metabolic syndrome.
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Published: 30 August 2016
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2016, Vol. 34 
