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| Effect of Butylphthalide Soft Capsules and Nimodipine on Patients with Vascular Dementia after Stroke |
| CHENG Wenyao, YANG Jian, YU Xinpei* |
| Office of Health Care, General Hospital of Guangzhou Military Command, Guangzhou 510010, China |
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Abstract Objective To observe and explore the effectiveness of butylphthalide soft capsules (NBP) and nimodipine (NMD) in patients with vascular dementia (VD) after stroke.Methods A total of 96 patients with VD in General Hospital of Guangzhou Military Command were selected between May 2012 and August 2015. They were randomized into two groups of 48 patients: the NBP group and NMD group. The NBP group was treated orally with NBP while the NMD group was treated orally with NMD for 6 months respectively. The efficacy was evaluated by the cognitive function scale (MMSE, MOCA) and daily life ability scale (ADL score) before treatment and at 3 months and 6 months after treatment.The incidence of adverse reactions in both groups was recorded.Results The difference in MMSE, MOCA and ADL scores before treatment between the two groups was not statistically significant (P>0.05), but MMSE and MOCA scores in the NBP group were significantly higher than those of the NMD group 3 months and 6 months after treatment, , while ADL score was significantly lower than that of the NMD group (P＜0.01). The adverse reaction rate was 10.4% (5/48) and 22.9% (11/48) respectively in the NBP group, and 22.9% (11/48) in the NMD group. The difference was statistically significant (P＜0.05).Conclusion Both NBP and NMD treatment can significantly improve the cognitive function and daily life ability of VD patients, and the curative effect is remarkable, but NBP is more effective and safer than NMD.
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Published: 14 September 2016
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2016, Vol. 34 
