血脑屏障中MMP-2、TIMP-2水平变化与脑神经胶质瘤侵袭能力的关系

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Abstract Objective To investigate the effects of tight junction of the blood-brain barrier on the glioma invasion ability.Methods 87 cases of neurosurgery glioblastoma patients including grade Ⅰ 29 cases,26 cases of patients with grade Ⅱ ,Ⅲ grade 21 cases ,Ⅳ grade 11 patients were enrolled.Serum levels in patients of S-100,GFAP,MMP-2,TIMP-2 were detected.Results S-100,GFAP in patients with grade Ⅱ compared with Ⅰ appeared significantly higher level(P<0.05),S-100,GFAP of Ⅲ grade patients compared with gradeⅠ,Ⅱ grade were significantly higher(P<0.05),S-100,GFAP of Ⅳ grade compared with gradeⅠ,Ⅱgrade ,grade Ⅲ were significantly(P<0.05).MMP-2 / TIMP-2 in Ⅱ level patients compared with class Ⅰ was significantly higher(P<0.05),MMP-2 and TIMP-2 in Ⅲ grade patients compared with grade Ⅰ were any significant different(P<0.05),MMP-2 / TIMP -2 compared with grade Ⅰ ,grade Ⅱ patients were significantly higher(P<0.05),MMP-2 and TIMP-2 and MMP-2 / TIMP-2 of Ⅳ grade compared with grade Ⅰ ,Ⅱ,Ⅲ were any significant different(P<0.05).S-100,GFAP and MMP-2,MMP-2 / TIMP-2 were significantly correlated(P<0.05),while showing no effects on TIMP-2(P>0.05).Conclusion With the progress of glioma grading ,the tight junction of BBB were destroyed and were closely related to glioma invasion ability.

Key words： glioma blood brain barrier invasive ability

Received: 28 February 2016 Published: 05 January 2017

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http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/EN/ OR http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/EN/Y2016/V34/I6/904

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