|
|
|
| Effects of the Compound Codonopsis on Cognitive Performance of Hypoxia Exposed Mice |
| WANG Weiguang, XIAO Zhonghai, YU Lixia*, HONG Yan* |
| Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China |
|
|
|
|
Abstract Objective To evaluate the effects of the compound codonopsis on cognitive function of mice exposed to hypobaric hypoxia.Methods A total of 36 adult male KM mice were randomly divided into three groups by weight (n=12) : normoxia control (NC), hypobaric hypoxia (HH), hypobaric hypoxia supplementation with the compound codonopsis (HHC). The animals of groups HH and HHC were exposed to hypoxia in a specially designed decompression chamber for 28 days. The desired altitude (5500 m) was reached at a rate of 15 m/s and maintained from 9.00 a.m. to 5.00 p.m. every day. Cognitive performances were examined by open field, passive avoidance and initiative avoidance tests.Results The movement capability and exploratory behavior of mice in HH group declined compared with NC group (P<0.05), while these capability and behavior of mice in HHC group were significantly higher than those in HH group (P<0.05). In the passive avoidance test, the latency to the dark department of mice in HH group (123.2?06.7 s) was distinctly shorter than controls (230.5?7.9 s) (P<0.05), but the latency in HHC (214.4?13.7 s) was significantly extended compared with HH group. In the shuttle box test, the active avoidance latency of the three groups showed "up-down" trends. The active avoidance latency of HH group was significantly increased in comparison with controls, while the latency of HHC mice become shorter after supplementation with the compound codonopsis (P<0.05). Conclusion Hypoxia exposure can impair learning and memory of mice, and the compound codonopsis can improve cognitive functions of hypoxia mice.
|
|
Published: 30 August 2016
|
|
|
|
| No related articles found! |
|
|
|
|
2016, Vol. 34 
