Abstract Objective To evaluate the effects of rosuvastatin combined with probucol on endothelial function in patients with hypertension and hyperlipemia.Methods A total of 84 postmenopausal patients with hypertension and hyperlipemia were randomly divided into rosuvastatin (10 mg/d) group (n=42) and rosuvastatin (10 mg/d) combined with probucol (500 mg/d) group (n=42).Serum lipids, glucose, liver and kidney function, endothelium-dependent flow-mediated dilatation (FMD) and endothelium-independent sublingual nitroglycerin-mediated dilatation(NMD) were detected before therapy and 3 months, 6 moths,1 years and 2 years after therapy.Results Compared to baseline value, the levels of total cholesterol and LDL-C decreased significantly 3 months after therapy in both groups (P<0.01), especially in combination group; The levels of these two parameters decreased with therapy time, and reached a steady state after 6 months therapy; There was no significant deference about the levels of these two parameters between 1 year after therapy and 2 years after therapy. FMD levels in 3 months after therapy and 2 years after therapy increased significantly compared to before therapy and 1 year after therapy, respectively in both groups (P<0.01), and FMD was significantly higher in rosuvastatin combined with probucol group than rosuvastatin group (P<0.01). NMD levels in 1 year after therapy and 2 years after therapy also increased significantly compared to before therapy in two groups but there was no statistical difference between two groups.Conclusion The rosuvastatin combined with probucol therapy was superior to rosuvastatin alone on improving endothelial function of postmenopausal patients with hypertension and hyperlipemia.
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Published: 30 August 2016
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