不同分期肝癌患者血清IGF-2及IGFBP-2水平与肝癌侵袭能力的相关性分析

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Abstract Objective To investigate the correlation of IGF-2 and IGFBP-2 with invasive ability in patients with liver cancer.Methods 124 cases of liver cancer patients were divided into stage I、II、III、IV.There were 29、31、36、28 patients in each stage separately. Levels of IGF-2, IGFBP -2, MMP-2 and TIMP-2 in the serum of patientswere detected.Results Levels of IGF-2 and IGFBP-2 in stage II patients were significantly higher (P<0.05)than in stage I. Levels of IGF-2 and IGFBP-2 were significantly higher in stage III than in stage I and II(P<0.05). Levels of IGF-2 and w IGFBP-2 were significantly different(P<0.05)from those in stageⅠ, Ⅱ, and Ⅲ. Levels of MMP-2 / TIMP-2 were significantly higher (P<0.05)in stage II than in stage I,while levels of MMP-2 and TIMP-2 in stage Ⅲ were significantly different(P<0.05)from those in stage I. Levels of MMP-2, TIMP-2 and MMP-2 / TIMP-2 were significantly different from those in stageⅠ , Ⅱ, and Ⅲ (P<0.05). IGF-2, TIMP-2, and MMP-2 / TIMP-2 were significantly correlated (P<0.05), so were IGFBP-2, TIMP-2, and MMP-2 / TIMP-2 (P<0.05).Conclusion With the progress of liver cancer, IGF-2 and IGFBP-2 levels are closely related to ECM remodelling ability , which is an important factor to reflect the invasive ability of cancer cells.

Key words： liver cancer IGF-2 IGFBP-2 MMP-2 TIMP-2

Received: 14 April 2016 Published: 05 January 2017

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http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/EN/ OR http://manu37.magtech.com.cn/Jwk_jsyxkx/jfj/EN/Y2016/V34/I6/866

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