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| Clinical Value of Serum Procalcitonin in Pneumonia Children with Sepsis |
| LI Hongguang, XU Xiaojun, YANG Jianrong①, WANG Chunming② |
| Department of Pediatrics, Family Planning Center Hospital of Yutian, Tangshan, Hebei 064200, China |
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Abstract Objective To explore the clinical significance and prognostic value of serum procalcitonin (PCT) in pneumonia children with sepsis. Methods A total of 80 pneumonia children with sepsis were divided into severe sepsis group (group A, n=30), sepsis group (group B, n=50), and another common pneumonia group (group C, n=60). Twenty-four hours after admission, the pediatric critical illness score (PCIS) was evaluated, serum PCT was detected by double antibodies sandiwich immuno-ELISA, the PCT and PCIS were compared between the three groups, the correlation of which was analyzed. All the patients were again divided into survival group (n=67) and death group(n=13) according to prognosis. The predictive value of PCT24 h,PCT72 h and PCT(72 h-24 h)/24 h for death rate within 21 days was analyzed by ROC. Results The serum PCT of group A, B and C after admission decreased gradually, but PCIS increased gradually(P<0.05). There was negative correlation between PCT and PCIS(r=-0.625, P<0.05). There was no significant difference in PCT24h between survival group and death group(P>0.05), but there was significant difference in PCT72h and PCT(72h-24h)/24h (P<0.05).When PCT24h was above8.79 ng/ml, PCT72h above9.36 ng/ml,and PCT(72h-24h)/24hwas below30.00%, the sensibility was e high when predicting the death of children within 21 d. Conclusion PCT and PCIS have a significant correlation and dynamic monitoring of PCT can facilitate prognosis of pneumonia children with sepsis.
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Published: 02 November 2016
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2016, Vol. 34 
