Objective To compare the difference of serum vitamin levels in umbilical vein and artery, and to analyze the relationship between serum vitamin levels in umbilical vein and artery and birth weight. Methods A total of 101 pairs of mothers and infants who were hospitalized in Danyang People's Hospital, Jiangsu Province from June to September, 2021 were recruited as the research participants. After delivery, umbilical vein and artery blood samples of the newborns were collected. The levels of vitamin A, vitamin B1, vitamin B2, niacinamide, folic acid, vitamin D, vitamin E and vitamin K1 were detected by liquid chromatography and mass spectrometry (LC-MS/MS). The level of vitamin B12 was detected by electrochemical luminescence method. The serum vitamin levels of umbilical artery and vein were compared by matching method, and the relationship between birth weight and the serum vitamin levels of umbilical artery and vein was analyzed by linear regression. Results The levels of 5-methyltetrahydrofolate, vitamin B2, niacinamide, vitamin A, vitamin E, 25-(OH) D3 in the serum of umbilical vein were higher than those in the serum of umbilical artery, and the level of vitamin B1 was lower. After correcting for serum albumin levels, the levels of vitamin B2, vitamin A, vitamin E and 25-(OH) D3 in the serum of umbilical vein were higher than those in the serum of umbilical artery, and the levels of vitamin B12, folic acid and vitamin B1 were lower. Linear regression results showed that after adjusting for pregnancy weight gain, newborn sex, gestational age, the logarithmic value of vitamin A in the serum of umbilical vein and artery was positively correlated with birth weight, while the difference of vitamin A levels between umbilical vein and artery was not statistically correlated with birth weight before and after adjustment. Conclusion There were differences in serum vitamin levels between umbilical vein and artery. Serum vitamin A levels in umbilical vein and artery were positively correlated with birth weight.
Key words
newborn /
birth weight /
umbilical cord /
vitamins /
cross sectional studies
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