[1] Dam H.The antihmorrhagic vitamin of the chick: occurrence and chemical nature[J]. Nature,1935,135: 652–653.
[2] Shea MK, Booth SL.Concepts and controversies in evaluating vitamin K status in population-based studies[J].Nutrients, 2016, 8: 8.
[3] Schurgers LJ, Vermeer C.Determination of phylloquinone and menaquinones in food[J].Haemostasis, 2000, 30: 298–307.
[4] Halder M, Petsophonsakul P, Akbulut AC, et al. Vitamin K: double bonds beyond coagulation insights into differences between vitamin K1 and K2 in health and disease[J]. Int J Mol Sci, 2019, 20: 896–896.
[5] Walther B, Karl JP, Booth SL, et al. Menaquinones, bacteria, and the food supply: the relevance of dairy and fermented food products to vitamin K requirements[J]. Adv Nutr, 2013, 4: 463–473.
[6] Schurgers LJ, Teunissen KJF, Hamulyák K, et al. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7[J]. Blood, 2007, 109: 3279–3283.
[7] Marles RJ, Roe AL, Oketch-Rabah HA.US Pharmacopeial convention safety evaluation of menaquinone-7, a form of vitamin K[J]. Nutr Rev, 2017, 75: 553–578.
[8] Marchili MR, Santoro E, Marchesi A, et al. Vitamin K deficiency: a case report and review of current guidelines[J].Ital J Pediatr, 2018, 44: 1–5.
[9] Araki S, Shirahata A.Vitamin K deficiency bleeding in infancy[J]. Nutrients, 2020, 12: 780.
[10] Inaba N, Sato T, Yamashita T.Low-dose daily intake of vitamin K₂ (menaquinone-7) improves osteocalcin γ-carboxylation: a double-blind, randomized controlled trials[J]. J Nutr Sci Vitaminol (Tokyo), 2015, 61: 471–480.
[11] 庄焕雄,陈东峰,徐孟凡,等. 维生素K₂对绝经后骨质疏松症的防治作用及血清组织蛋白酶K影响[J].中国骨质疏松杂志, 2017, 23: 627–630.
[12] Knapen MHJ, Drummen NE, Smit E, et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women[J]. Osteo-poros Int, 2013, 24: 2499–2507.
[13] 胥小琴,张丹,陶新城,等. 维生素K₂防治绝经后骨质疏松症作用的荟萃分析[J]. 中国骨质疏松杂志, 2021, 27: 1780–1787.
[14] 夏玉,殷光玲. 维生素K₂防治骨质疏松症的研究进展[J]. 生物技术世界,2016(3):184–185.
[15] 周建烈,陈杰鹏,段丽丽,等. 维生素K₂(MK-7)防治骨质疏松的作用机制研究进展[J]. 中国骨质疏松杂志, 2019, 25: 539–545.
[16] Geleijnse JM, Vermeer C, Grobbee DE, et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study[J]. J Nutr, 2004, 134: 3100–3105.
[17] Vossen LM, Schurgers LJ, Van Varik BJ, et al. Menaquinone-7 supplementation to reduce vascular calcification in patients with coronary artery disease: rationale and study protocol (VitaK-CAC Trial)[J]. Nutrients, 2015, 7: 8905–8915.
[18] Hariri E, Kassis N, Iskandar JP, et al. Vitamin K₂—a neglected player in cardiovascular health: a narrative review[J]. Open Heart, 2021, 8: e001715.
[19] 曹安澜,赖雨薇,陈亨贵,等. 维生素K与2型糖尿病关系的研究进展[J].中华预防医学杂志,2020,54:555–562.
[20] Zhong JH, Mo XS, Xiang BD, et al. Postoperative use of the chemopreventive vitamin K₂ analog in patients with hepatocellular carcinoma[J]. PLoS One, 2013, 8: e58082.
[21] Popescu A, German M.Vitamin K₂ holds promise for Alzheimer's prevention and treatment[J].Nutrients, 2021, 13: 2206.
[22] Mong MA.Vitamin K and the visual system—a narrative review[J]. Nutrients,2023,15:1948.
[23] Dofferhoff ASM, Piscaer I, Schurgers LJ, et al. Reduced vitamin K status as a potentially modifiable risk factor of severe coronavirus disease 2019[J]. Clin Infect Dis, 2021,73:e4039–e4046.
[24] Janssen R, Visser MPJ, Dofferhoff ASM, et al. Vitamin K metabolism as the potential missing link between lung damage and thromboembolism in Coronavirus disease 2019[J].Br J Nutr, 2021, 126: 191–198.
[25] De Brouwer B, Piscaer I, Von Der Thusen JH, et al. Should vitamin K be supplemented instead of antagonised in patients with idiopathic pulmonary fibrosis?[J]. Expert Rev Respir Med, 2018, 12: 169–175.
[26] Schwalfenberg GK.Vitamins K₁ and K₂: the emerging group of vitamins required for human health[J]. J Nutr Metab, 2017,2017: 6254836.
[27] Shearer MJ, Fu X, Booth SL.Vitamin K nutrition, metabolism, and requirements: current concepts and future research[J].Adv Nutr,2012,3: 182–195.
[28] Shearer M J, McBurney A, Barkhan P. Studies on the absorption and metabolism of phylloquinone (vitamin K₁) in man[J]. Vitam Horm,1975,32: 513–542.
[29] Schurgers LJ, Vermeer C.Differential lipoprotein transport pathways of K-vitamins in healthy subjects[J]. Biochim Biophys Acta, 2002, 1570: 27–32.
[30] Sato T, Schurgers LJ, Uenishi K.Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women[J].Nutr J, 2012,11:93.
[31] Jones KS, Bluck LJC, Wang LY, et al. The effect of different meals on the absorption of stable isotope-labelled phylloquinone[J]. Br J Nutr, 2009, 102: 1195–1202.
[32] Turck D, Bresson J, Burlingame B, et al. Dietary reference values for vitamin K[J]. EFSA J, 2017, 15: e04780.
[33] Uematsu T, Nagashima S, Niwa M, et al. Effect of dietary fat content on oral bioavailability of menatetrenone in humans[J].J Pharm Sci, 1996, 85: 1012–1016.
[34] McDonald MG, Rieder MJ, Nakano M, et al. CYP4F2 is a vitamin K1 oxidase: an explanation for altered warfarin dose in carriers of the V433M variant[J]. Mol Pharmacol, 2009, 75: 1337–1346.
[35] Yan L, Zhou B, Nigdikar S, et al. Effect of apolipoprotein E genotype on vitamin K status in healthy older adults from China and the UK[J]. Br J Nutr, 2005, 94: 956–961.
[36] Newman P, Bonello F, Wierzbicki AS, et al. The uptake of lipoprotein‐borne phylloquinone (vitamin K1) by osteoblasts and osteoblast‐like cells: role of heparan sulfate proteoglycans and apolipoprotein E[J]. J Bone Miner Res, 2002, 17: 426–433.
[37] Macdonald HM, McGuigan FE, Lanham-New SA, et al. Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymerphisms[J]. Am J Clin Nutr, 2008, 87: 1513–1520.
[38] Crosier MD, Peter I, Booth SL, et al. Association of sequence variations in vitamin K epoxide reductase and γ-glutamyl carboxylase genes with biochemical measures of vitamin K status[J].J Nutr Sci Vitaminol (Tokyo), 2009, 55: 112–119.
[39] Shearer MJ, Newman P.Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis[J]. J Lipid Res, 2014,55: 345–362.
[40] Shearer MJ, Newman P.Metabolism and cell biology of vitamin K[J]. Thromb Haemost, 2008, 100: 530–547.
[41] Goncalves A, Margier M, Roi S, et al. Intestinal scavenger receptors are involved in vitamin K1 absorption[J].J Biol Chem, 2014, 289: 30743–30752.
[42] Takada T, Yamanashi Y, Konishi K, et al. NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy[J]. Sci Transl Med, 2015,7: 275ra23.
[43] Shearer M J, Okano T.Key pathways and regulators of vitamin K function and intermediary metabolism[J]. Annu Rev Nutr, 2018, 38: 127–151.
[44] 中川公恵. ビタミン K の生体内変換機構の消失により起こる疾患とその予防[J].薬学雑誌,2021,41:669-674.
[45] Okano T, Shimomura Y, Yamane M, et al. Conversion of phylloquinone (Vitamin K1) into menaquinone-4 (Vitamin K2) in mice: two possible routes for menaquinone-4 accumulation in cerebra of mice[J]. J Biol Chem, 2008, 283: 11270–11279.
[46] Hirota Y, Tsugawa N, Nakagawa K, et al. Menadione (vitamin K3) is a catabolic product of oral phyllo-quinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone–4 (vitamin K₂) in rats[J]. J Biol Chem, 2013, 288: 33071–33080.
[47] Novotny JA, Kurilich AC, Britz SJ, et al. Vitamin K absorption and kinetics in human subjects after consumption of ¹³C–labelled phylloquinone from kale[J]. Br J Nutr, 2010, 104: 858–862.
[48] Thijssen HHW.Vitamin K status in human tissues: tissue-specific accumulation of phylloquinone and menaquinone–4[J]. Br J Nutr, 1996, 75: 121–127.
[49] Thijssen HHW, Drittij-Reijnders MJ.Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone–4[J]. Br J Nutr, 1994, 72: 415–425.
[50] Usui Y, Tanimura H, Nishimura N, et al. Vitamin K concentrations in the plasma and liver of surgical patients[J]. Am J Clin Nutr, 1990, 51: 846–852.
[51] Card D J, Gorska R, Cutler J, et al. Vitamin K metabolism: current knowledge and future research[J]. Mol Nutr Food Res,2014,58: 1590–1600.
[52] Thijssen HHW, Vervoort LMT, Schurgers LJ, et al. Menadione is a metabolite of oral vitamin K[J]. Br J Nutr, 2006, 95: 260–266.