ASSOCIATIONS BETWEEN SERUM 25-HYDROXYVITAMIN D3 LEVEL AND THE PREVALENCES OF DIABETES AND ABNORMAL BLOOD GLUCOSE IN A CHINESE ADULT POPULATION

WANG Jin-xiu; LIU Zi-yue; WANG Chun-yang; BI Yan-ming; WANG Wen; HU Zhi-yong

Acta Nutrimenta Sinica ›› 2024, Vol. 46 ›› Issue (2) : 132-138.

ASSOCIATIONS BETWEEN SERUM 25-HYDROXYVITAMIN D₃ LEVEL AND THE PREVALENCES OF DIABETES AND ABNORMAL BLOOD GLUCOSE IN A CHINESE ADULT POPULATION

WANG Jin-xiu, LIU Zi-yue, WANG Chun-yang, BI Yan-ming, WANG Wen, HU Zhi-yong

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Abstract

Objective To explore the associations between serum vitamin D (VD) level and the prevalences of diabetes/abnormal blood glucose in a Chinese population. Methods A total of 2072 eligible subjects over 18 years of age were included by the multi-stage sampling method. Serum 25 hydroxyvitamin D₃ (25(OH)D₃) level and lipid metabolism indexes were detected, and relevant demographic and physical information were collected. Multiple logistic regression analysis was used to examine the relationship between serum 25(OH)D₃level and the prevalences of diabetes and abnormal blood glucose. Results The prevalence of diabetes was 5.69%, the rate of abnormal blood glucose was 54.68%, and the rate of vitamin D deficiency was 19.79%. The rate of vitamin D deficiency was 28.81% in diabetic subjects and 19.59% in abnormal blood glucose subjects. The prevalence of diabetes in subjects with vitamin D deficiency was significantly higher than that in subjects with vitamin D sufficiency (8.25% vs 5.06%, P=0.012), while there was no statistically significant difference in the rates of abnormal blood glucose between the subjects with vitamin D deficiency and vitamin D sufficiency (20.83% vs 19.59%, P=0.716). After adjusting for multiple factors such as age, region, exercise, BMI, fasting lipids, and blood pressure, the decrease of serum 25 (OH) D₃ level was associated with a higher prevalence of diabetes (P=0.046), and the risk of diabetes/abnormal blood glucose was increased by 1.391 (1.039-1.861) times for every 10 ng/ml decrease in serum 25(OH)D₃ level (P=0.026). After further stratification of the diabetic subjects, compared with the vitamin D adequate group, the risk of diabetes in the vitamin D deficiency group was 1.594 (1.009-2.520, P=0.046) after multi-factor adjustment. The risk of diabetes was increased by 1.391 (1.039-1.861) times for every 10 ng/ml decrease in serum vitamin D₃ level (P=0.026). Conclusion Vitamin D deficiency may be an independent risk factor for high incidence of diabetes in Chinese adult population.

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vitamin D / diabetes mellitus / dysglycemia

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WANG Jin-xiu, LIU Zi-yue, WANG Chun-yang, BI Yan-ming, WANG Wen, HU Zhi-yong. ASSOCIATIONS BETWEEN SERUM 25-HYDROXYVITAMIN D₃ LEVEL AND THE PREVALENCES OF DIABETES AND ABNORMAL BLOOD GLUCOSE IN A CHINESE ADULT POPULATION[J]. Acta Nutrimenta Sinica. 2024, 46(2): 132-138

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