IMPROVEMENTS OF GUT HEALTH BY OAT &#x003b2;-GLUCAN BASED PREBIOTIC BLENDING FORMULAS IN ADULTS WITH DEFECATION DIFFICULTY

LI Ai-qi; JIN Lei; WANG Xin; XU Hai; LIU Lie-gang; SUN Gui-ju

Acta Nutrimenta Sinica ›› 2024, Vol. 46 ›› Issue (3) : 228-234.

ORIGINAL ARTICLES

IMPROVEMENTS OF GUT HEALTH BY OAT β-GLUCAN BASED PREBIOTIC BLENDING FORMULAS IN ADULTS WITH DEFECATION DIFFICULTY

LI Ai-qi¹, JIN Lei², WANG Xin³, XU Hai¹, LIU Lie-gang², SUN Gui-ju¹

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Abstract

Objective To investigate the effects of oat β-glucan based prebiotic blending formulas on gut health. Methods The 24 h and 48 h in vitro fermentations on two oat β-glucan based prebiotic blending formulas using human feces were conducted. The effects of two formulas on gut bacteria were explored by qPCR and 16S rDNA approaches. Subsequently, a two-center parallel double-blind randomized controlled human trial was conducted in 192 adults with defecation difficulty. The participants were randomly assigned to one of three groups with a 28-day intervention. During the intervention, human fecal samples were collected and defecation feelings were investigated. The data were analyzed using generalized mixed linear model, t-test and ANCOVA. Results The results of both in vitro test and human trial found that, compared to control group, oat β-glucan based prebiotic blending formulas could promote the growth of Faecalibacterium prausnitzii, Akkermansia muciniphila, Holdemania and Blautia (P<0.05). Oat β-glucan based prebiotic blending formulas also improved the defecation difficulty and digestive feeling(P<0.05). Conclusion Oat β-glucan based prebiotic blending formulas can promote the growth of gut beneficial bacteria, and improve gut health in adults with defecation difficulty.

Key words

oats β-glucan / prebiotic / invitro fermentation / human trial / gut bacteria / defecation

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LI Ai-qi, JIN Lei, WANG Xin, XU Hai, LIU Lie-gang, SUN Gui-ju. IMPROVEMENTS OF GUT HEALTH BY OAT β-GLUCAN BASED PREBIOTIC BLENDING FORMULAS IN ADULTS WITH DEFECATION DIFFICULTY[J]. Acta Nutrimenta Sinica. 2024, 46(3): 228-234

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