EFFECT OF PROBIOITIC SUPPLEMENTATION ON DEPRESSION STATUS IN PREGNANT WOMEN AT HIGH RISK OF GESTATIONAL DIABETES MELLITUS

WANG Jin-jing; SUN Ji-han; MIAO Miao; DAI Yong-mei; WANG Jiong-nan; SUN Gui-ju

Acta Nutrimenta Sinica ›› 2024, Vol. 46 ›› Issue (4) : 328-333.

WANG Jin-jing¹, SUN Ji-han¹, MIAO Miao², DAI Yong-mei², WANG Jiong-nan¹, SUN Gui-ju¹

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Abstract

Objective To observe the effect of probiotics on the depression status in pregnant women at high risk of gestational diabetes mellitus (GDM), and to provide new ideas for improving the depression status. Methods A total of 446 pregnant women with high risk factors of GDM in Nanjing Maternal and Child Health Hospital from June 2020 to June 2021 were randomly divided into probiotics group (n=223) and placebo control group (n=223). From the first trimester (within 15 weeks) to the third trimester until delivery, one sachet of probiotics or placebo was administered per day. The depression status of the high-risk GDM groups with in the second trimester (24-28 weeks) and third trimester (34-36 weeks) at the time of enrollment (within 15 weeks) was evaluated through questionnaire and the depression self-rating scale. Results After 22 weeks of intervention, the depression status of the probiotic group was significantly improved compared with that of the control group (P<0.05). Compared with before the intervention, the depression status of the depressed pregnant women in the high risk GDM group decreased significantly after 12 and 22 weeks of intervention (P<0.01). Conclusion The depression status of the pregnant women at high risk of GDM can be improved by supplementing probiotics.

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probiotics / depression / high GDM risk pregnant women

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WANG Jin-jing, SUN Ji-han, MIAO Miao, DAI Yong-mei, WANG Jiong-nan, SUN Gui-ju. EFFECT OF PROBIOITIC SUPPLEMENTATION ON DEPRESSION STATUS IN PREGNANT WOMEN AT HIGH RISK OF GESTATIONAL DIABETES MELLITUS[J]. Acta Nutrimenta Sinica. 2024, 46(4): 328-333

References

[1] Herrman H, Patel V, Kieling C, et al. Time for united action on depression: a Lancet-World Psychiatric Association Commission[J].Lancet,2022,399: 957–1022.
[2] Lu J, Xu X, Huang Y, et al. Prevalence of depressive disorders and treatment in China: a cross-sectional epidemiological study[J]. Lancet Psychiatry, 2021, 8: 981–990.
[3] Bennett HA, Einarson A, Taddio A, et al. Prevalence of depression during pregnancy: systematic review[J]. Obstet Gynecol, 2004, 103: 698–709.
[4] Wilson CA, Newham J, Rankin J, et al. Is there an increased risk of perinatal mental disorder in women with gestational diabetes? A systematic review and meta-analysis[J]. Diabet Med, 2020, 37: 602–622.
[5] 周翔, 雷梦媛, 梁丹丹, 等. 妊娠期糖尿病与产后抑郁关系的Meta分析[J]. 现代预防医学, 2021, 48: 571–576.
[6] Hill C, Guarner F, Reid G, et al. Expert consensus document. The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic[J]. Nat Rev Gastroenterol Hepatol, 2014, 11: 506–514.
[7] Miller AH, Raison CL.The role of inflammation in depression: from evolutionary imperative to modern treatment target[J]. Nat Rev Immunol, 2016, 16: 22–34.
[8] 李郦. 妊娠期糖尿病患者实施心理护理对血糖控制情况焦虑自评量表抑郁自评量表评分及产后转内科情况的影响[J].中国药物与临床, 2020, 20: 3689–3691.
[9] Slykerman RF, Hood F, Wickens K, et al. Effect of Lactobacillus rhamnosus HN001 in pregnancy on postpartum symptoms of depression and anxiety: a randomised double-blind placebo-controlled trial[J]. EBioMedicine, 2017, 24: 159–165.
[10] Shelly AB, Sean WD, Martina S, et al. Dissecting the contribution of host genetics and the microbiome in complex behaviors[J]. Cell, 2021,184: 1740–1756.
[11] Tian PJ, Zou RY, Wang LY, et al. Multi-probiotics ameliorate major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation[J]. J Adv Res, 2023, 45:117–125.
[12] Ng QX, Peters C, Ho CYX, et al. A meta-analysis of the use of probiotics to alleviate depressive symptoms[J]. J Affect Disord, 2018, 228: 13–19.
[13] Barthow C, Wickens K, Stanley T, et al. The Probiotics in Pregnancy Study (PiP Study): rationale and design of a double-blind randomised controlled trial to improve maternal health during pregnancy and prevent infant eczema and allergy[J]. BMC Pregnancy Childbirth, 2016, 16: 133.
[14] Hinkle SN, Buck Louis G, Rawal S, et al. A longitudinal study of depression and gestational diabetes in pregnancy and the postpartum period[J]. Diabetologia, 2016, 59: 2594–2602.
[15] Browne PD, Bolte AC, Besseling-van der Vaart I, et al. Probiotics as a treatment for prenatal maternal anxiety and depression: a double-blind randomized pilot trial[J]. Sci Rep, 2021, 11: 3051.